Department of Chemical & Biomolecular Engineering, National University of Singapore, Kent Ridge, Singapore 119260.
Langmuir. 2011 Jun 7;27(11):7065-76. doi: 10.1021/la200620s. Epub 2011 May 13.
Barnacle cement (BC) was beneficially applied on stainless steel (SS) to serve as the initiator anchor for surface-initiated polymerization. The amine and hydroxyl moieties of barnacle cement reacted with 2-bromoisobutyryl bromide to provide the alkyl halide initiator for the surface-initiated atom transfer radical polymerization (ATRP) of 2-hydroxyethyl methacrylate (HEMA). The hydroxyl groups of HEMA polymer (PHEMA) were then converted to carboxyl groups for coupling of chitosan (CS) to impart the SS surface with both antifouling and antibacterial properties. The surface-functionalized SS reduced bovine serum albumin adsorption, bacterial adhesion, and exhibited antibacterial efficacy against Escherichia coli (E. coli). The effectiveness of barnacle cement as an initiator anchor was compared to that of dopamine, a marine mussel inspired biomimetic anchor previously used in surface-initiated polymerization. The results indicate that the barnacle cement is a stable and effective anchor for functional surface coatings and polymer brushes.
藤壶水泥 (BC) 被有益地应用于不锈钢 (SS) 上，作为表面引发聚合的起始锚固剂。藤壶水泥的胺基和羟基与 2-溴异丁酰溴反应，为 2-羟乙基甲基丙烯酸酯 (HEMA) 的表面引发原子转移自由基聚合 (ATRP) 提供了卤代烷基引发剂。HEMA 聚合物 (PHEMA) 的羟基随后被转化为羧基，用于壳聚糖 (CS) 的偶联，赋予 SS 表面抗污和抗菌性能。表面功能化的 SS 减少了牛血清白蛋白的吸附、细菌黏附，并对大肠杆菌 (E. coli) 表现出抗菌功效。藤壶水泥作为引发锚固剂的有效性与先前用于表面引发聚合的海洋贻贝仿生生物模拟锚固剂多巴胺进行了比较。结果表明，藤壶水泥是功能表面涂层和聚合物刷的稳定且有效的锚固剂。
