Rentala Satyanarayana, Konada Sudhakar, Chintala Ramakrishna, Mangamoori Lakshmi Narasu, Upadhyayula Suryanarayana Murthy, Dhurjeti Sarva Mangala
Department of Biotechnology, GITAM Institute of Technology, GITAM University, Rushikonda, Visakhapatnam - 530 045, INDIA.
Bioinformation. 2013 Aug 7;9(14):721-4. doi: 10.6026/97320630009721. eCollection 2013.
Vitamin C, Vitamin E, scopoletin and damnacanthal are the major constituents of Noni (Morinda citrifolia). These compounds are known to have good medicinal properties and they are known to act as antioxidants. Loss of vision in elderly is due to opaqueness of the lens proteins such as gamma-D-crystallin during oxidative stress conditions. Therefore, it is of importance to find the potential interaction of Vitamin C, Vitamin E, Scopoletin and Damnacanthal with the lens protein gamma-D-crystallin. Hence, their physical binding to gamma-D crystallin (PDB ID: 2G98) was evaluated using molecular and structural docking procedures. Results show the potential binding of all the above anti-oxidants to gamma-D-crystalline with equal affinity. Thus, the role of cumulative anti-oxidant effect in Noni fruit juice through their potential yet predicted interaction with the lens protein gamma-D-crystallin is implied for cataract treatment.
维生素C、维生素E、东莨菪亭和虎刺醛是诺丽果（海巴戟）的主要成分。已知这些化合物具有良好的药用特性，并且它们作为抗氧化剂发挥作用。老年人视力丧失是由于氧化应激条件下晶状体蛋白（如γ-D-晶状体蛋白）的不透明性所致。因此，研究维生素C、维生素E、东莨菪亭和虎刺醛与晶状体蛋白γ-D-晶状体蛋白之间的潜在相互作用具有重要意义。因此，使用分子和结构对接程序评估了它们与γ-D-晶状体蛋白（PDB ID：2G98）的物理结合。结果表明，上述所有抗氧化剂与γ-D-晶状体蛋白具有同等亲和力的潜在结合。因此，诺丽果汁中累积抗氧化作用通过其与晶状体蛋白γ-D-晶状体蛋白潜在但可预测的相互作用在白内障治疗中的作用得以体现。
