评估胆酰基['14C]甘氨酸的血浆消失情况作为肝细胞疾病的一项检测。
Assessment of the plasma disappearance of cholyl'l14C-glycine as a test of hepatocellular disease.
作者信息
Thjodleifsson B, Barnes S, Chitranukroh A, Billing B H, Sherlock S
出版信息
Gut. 1977 Sep;18(9):697-702. doi: 10.1136/gut.18.9.697.
Abstract
The plasma disappearance of a tracer dose of cholyl-l14C-glycine has been examined in 12 control subjects and in 32 patients with hepatocellular dysfunction. Simple analysis of the data did not detect hepatic dysfunction except in severe hepatocellular disease. The greatest degree of discrimination between normal subjects and patients with mild liver disease was obtained by taking the ratio of the plasma retention at 60 minutes to that at 10 minutes; it was similar to that obtained with serum gamma-glutamyl transferase. The two hour post-prandial plasma "total" bile acid concentration gave complete separation between the control subjects and patients with liver disease.
摘要
在12名对照受试者和32名肝细胞功能障碍患者中，研究了示踪剂量的胆酰 - l14C - 甘氨酸的血浆消失情况。对数据进行简单分析时，除了在严重肝细胞疾病中，未检测到肝功能障碍。通过计算60分钟时与10分钟时血浆潴留的比值，在正常受试者和轻度肝病患者之间获得了最大程度的区分度；这与血清γ - 谷氨酰转移酶的区分度相似。餐后两小时血浆“总”胆汁酸浓度能完全区分对照受试者和肝病患者。
相似文献
1
Assessment of the plasma disappearance of cholyl'l14C-glycine as a test of hepatocellular disease.评估胆酰基['14C]甘氨酸的血浆消失情况作为肝细胞疾病的一项检测。
Gut. 1977 Sep;18(9):697-702. doi: 10.1136/gut.18.9.697.
2
Plasma disappearance of intravenously injected radiolabelled glycocholic acid in patients with liver disease.肝病患者静脉注射放射性标记甘氨胆酸后的血浆清除情况。
Aust N Z J Med. 1977 Apr;7(2):148-50. doi: 10.1111/j.1445-5994.1977.tb04682.x.
3
Kinetics of 14C-glycocholic acid clearance in normal man and in patients with liver disease.正常人及肝病患者体内14C-甘氨胆酸清除的动力学
Gut. 1978 Dec;19(12):1110-5. doi: 10.1136/gut.19.12.1110.
4
Bile acid clearance in liver disease.肝病中的胆汁酸清除率
Gut. 1979 Dec;20(12):1083-7. doi: 10.1136/gut.20.12.1083.
5
[Serum cholylglycine in the evaluation of impaired hepatic function].[血清甘氨胆酰在肝功能损害评估中的应用]
Minerva Med. 1986 Apr 21;77(17):687-91.
6
Plasma disappearance of 14C-glycocholic acid as a test of liver dysfunction. Relation to liver histology.以14C-甘氨胆酸的血浆消失作为肝功能障碍的一项检测。与肝脏组织学的关系。
Scand J Gastroenterol. 1985 Mar;20(2):175-8. doi: 10.3109/00365528509089652.
7
Clinical value of bile salt tests in anicteric liver disease.胆汁盐检测在无黄疸型肝病中的临床价值
Gut. 1981 Feb;22(2):141-8. doi: 10.1136/gut.22.2.141.
8
Diagnostic values of fasting and postprandial concentrations in serum of 3 alpha-hydroxy-bile acids and gamma-glutamyl transferase in hepatobiliary disease.
Scand J Gastroenterol. 1983 Jan;18(1):49-56. doi: 10.3109/00365528309181558.
9
[Determination of serum bile acids in hepatobiliary diseases. Clinical applicability].[肝胆疾病中血清胆汁酸的测定。临床应用]
Minerva Med. 1984 Jan 28;75(3-4):99-107.
10
Evaluation of the diagnostic value of serum bile acid in the detection and functional assessment of liver diseases.血清胆汁酸在肝脏疾病检测及功能评估中的诊断价值评估
Ann Clin Biochem. 1985 Nov;22 ( Pt 6):596-605. doi: 10.1177/000456328502200608.
引用本文的文献
1
Diagnosis of hepatocellular carcinoma using a novel anti-glycocholic acid monoclonal antibody-based method.使用一种基于新型抗甘氨胆酸单克隆抗体的方法诊断肝细胞癌。
Oncol Lett. 2019 Mar;17(3):3103-3112. doi: 10.3892/ol.2019.9943. Epub 2019 Jan 17.
2
Serum Bile Acids Are Associated with Pathological Progression of Hepatitis B-Induced Cirrhosis.血清胆汁酸与乙型肝炎所致肝硬化的病理进展相关。
J Proteome Res. 2016 Apr 1;15(4):1126-34. doi: 10.1021/acs.jproteome.5b00217. Epub 2016 Mar 22.
3
Profiles of serum bile acids in liver diseases.肝脏疾病中的血清胆汁酸谱。
Korean J Intern Med. 1986 Jan;1(1):37-42. doi: 10.3904/kjim.1986.1.1.37.
4
Cholyllysyl fluroscein and related lysyl fluorescein conjugated bile acid analogues.胆酰赖氨酰荧光素及相关的赖氨酰荧光素共轭胆汁酸类似物。
Yale J Biol Med. 1997 Jul-Aug;70(4):447-57.
5
Plasma clearance of oral and intravenous cholic acid in subjects with and without chronic liver disease.患有和未患有慢性肝病的受试者口服和静脉注射胆酸后的血浆清除率。
Gut. 1980 Feb;21(2):123-7. doi: 10.1136/gut.21.2.123.
6
Rifampicin-induced elevation of serum bile acids in man.利福平引起人体血清胆汁酸升高。
Dig Dis Sci. 1980 Feb;25(2):108-12. doi: 10.1007/BF01308307.
7
Oral ursodeoxycholic acid tolerance test in patients with digestive disease.消化系统疾病患者的口服熊去氧胆酸耐受性试验
Gastroenterol Jpn. 1981;16(5):472-7. doi: 10.1007/BF02774519.
8
Clinical value of serum bile acid levels in chronic hepatitis.血清胆汁酸水平在慢性肝炎中的临床价值
Dig Dis Sci. 1981 Nov;26(11):978-83. doi: 10.1007/BF01314758.
9
Clinical value of bile salt tests in anicteric liver disease.胆汁盐检测在无黄疸型肝病中的临床价值
Gut. 1981 Feb;22(2):141-8. doi: 10.1136/gut.22.2.141.
10
Colorimetric enzymatic measurement of serum total 3 alpha-hydroxy bile acid concentrations without extraction.无需提取的血清总3α-羟基胆汁酸浓度的比色酶法测定
J Clin Pathol. 1984 Mar;37(3):317-20. doi: 10.1136/jcp.37.3.317.
本文引用的文献
1
CLINICAL STUDIES OF THE BLOOD VOLUME. I. CLINICAL APPLICATION OF A METHOD EMPLOYING THE AZO DYE "EVANS BLUE" AND THE SPECTROPHOTOMETER.血容量的临床研究。I. 一种使用偶氮染料“伊文思蓝”和分光光度计的方法的临床应用。
J Clin Invest. 1937 May;16(3):301-16. doi: 10.1172/JCI100859.
2
New solvent systems for thin-layer chromatography of bile acids.用于胆汁酸薄层色谱分析的新型溶剂系统。
J Lipid Res. 1966 Jul;7(4):579-81.
3
Radioimmunoassay of conjugated cholyl bile acids in serum.血清中结合胆酰胆汁酸的放射免疫测定
Gastroenterology. 1973 Nov;65(5):705-11.
4
Postprandial serum bile acid for the detection of hepatobiliary disease.餐后血清胆汁酸用于肝胆疾病的检测。
JAMA. 1973 Jul 16;225(3):292-3.
5
Factors affecting plasma clearance of (14C) cholic acid in patients with cirrhosis.肝硬化患者中影响（14C）胆酸血浆清除率的因素。
Clin Sci Mol Med. 1973 Aug;45(2):147-61. doi: 10.1042/cs0450147.
6
Factors affecting drug metabolism.影响药物代谢的因素。
Ann N Y Acad Sci. 1971 Jul 6;179:43-66. doi: 10.1111/j.1749-6632.1971.tb46890.x.
7
A fluorimetric and enzymatic method for the estimation of serum total bile acids.一种用于估算血清总胆汁酸的荧光酶法。
J Clin Pathol. 1970 Oct;23(7):594-8. doi: 10.1136/jcp.23.7.594.
8
[Diagnostic significance of serum bile acids].[血清胆汁酸的诊断意义]
Schweiz Med Wochenschr. 1975 Apr 26;105(17):533-5.
9
Diagnositic value of serum bile acid estimations in liver disease.血清胆汁酸测定在肝脏疾病中的诊断价值。
J Clin Pathol. 1975 Jun;28(6):506-9. doi: 10.1136/jcp.28.6.506.
10
Plasma disappearance of radioactivity after intravenous injection of labeled bile acids in man.人体静脉注射标记胆汁酸后放射性物质在血浆中的消失情况。
Gastroenterology. 1975 Jun;68(6):1567-73.
Zotero 插件