评估胆酰基['14C]甘氨酸的血浆消失情况作为肝细胞疾病的一项检测。
Assessment of the plasma disappearance of cholyl'l14C-glycine as a test of hepatocellular disease.
作者信息
Thjodleifsson B, Barnes S, Chitranukroh A, Billing B H, Sherlock S
出版信息
Gut. 1977 Sep;18(9):697-702. doi: 10.1136/gut.18.9.697.
Abstract
The plasma disappearance of a tracer dose of cholyl-l14C-glycine has been examined in 12 control subjects and in 32 patients with hepatocellular dysfunction. Simple analysis of the data did not detect hepatic dysfunction except in severe hepatocellular disease. The greatest degree of discrimination between normal subjects and patients with mild liver disease was obtained by taking the ratio of the plasma retention at 60 minutes to that at 10 minutes; it was similar to that obtained with serum gamma-glutamyl transferase. The two hour post-prandial plasma "total" bile acid concentration gave complete separation between the control subjects and patients with liver disease.
摘要
在12名对照受试者和32名肝细胞功能障碍患者中，研究了示踪剂量的胆酰 - l14C - 甘氨酸的血浆消失情况。对数据进行简单分析时，除了在严重肝细胞疾病中，未检测到肝功能障碍。通过计算60分钟时与10分钟时血浆潴留的比值，在正常受试者和轻度肝病患者之间获得了最大程度的区分度；这与血清γ - 谷氨酰转移酶的区分度相似。餐后两小时血浆“总”胆汁酸浓度能完全区分对照受试者和肝病患者。
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