From the Departments of Biochemistry.
J Biol Chem. 2013 Oct 11;288(41):29746-59. doi: 10.1074/jbc.M113.487595. Epub 2013 Aug 28.
The promyelocytic leukemia protein is a well known tumor suppressor, but its role in metabolism is largely unknown. Mice with a deletion in the gene for PML (KO mice) exhibit altered gene expression in liver, adipose tissue, and skeletal muscle, an accelerated rate of fatty acid metabolism, abnormal glucose metabolism, constitutive AMP-activating kinase (AMPK) activation, and insulin resistance in skeletal muscle. Last, an increased rate of energy expenditure protects PML KO mice from the effects of obesity induced by a Western diet. Collectively, our study uncovers a previously unappreciated role of PML in the regulation of metabolism and energy balance in mice.
早幼粒细胞白血病蛋白是一种众所周知的肿瘤抑制因子，但它在代谢中的作用在很大程度上尚不清楚。PML 基因缺失的小鼠（KO 小鼠）在肝脏、脂肪组织和骨骼肌中表现出基因表达改变、脂肪酸代谢加速、葡萄糖代谢异常、AMP 激活激酶（AMPK）持续激活以及骨骼肌胰岛素抵抗。最后，能量消耗的增加保护 PML KO 小鼠免受西方饮食引起的肥胖的影响。总的来说，我们的研究揭示了 PML 在调节小鼠代谢和能量平衡中的一个以前未被认识的作用。
