Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109-5942, USA.
Immunotherapy. 2013 Sep;5(9):989-1004. doi: 10.2217/imt.13.101.
During immune responses, T cells require tightly controlled expression of transcriptional programs to regulate the balance between beneficial and harmful immunity. These transcriptional programs are critical for the lineage specification of effector T cells, the production of effector cytokines and molecules, and the development and maintenance of memory T cells. An emerging theme is that post-translational modification of histones by methylation plays an important role in orchestrating the expression of transcriptional programs in T cells. In this article, we provide a broad overview of histone methylation signatures for effector molecules and transcription factors in T cells, and the functional importance of histone methyltransferases in regulating T-cell immune responses.
在免疫反应中，T 细胞需要严格控制转录程序的表达，以调节有益和有害免疫之间的平衡。这些转录程序对于效应 T 细胞的谱系特异性、效应细胞因子和分子的产生以及记忆 T 细胞的发育和维持至关重要。一个新出现的主题是，组蛋白的甲基化等翻译后修饰在协调 T 细胞中转录程序的表达中起着重要作用。在本文中，我们提供了 T 细胞中效应分子和转录因子的组蛋白甲基化特征的广泛概述，以及组蛋白甲基转移酶在调节 T 细胞免疫反应中的功能重要性。
