在冠状动脉疾病的发展过程中，内皮功能障碍。
Endothelial dysfunction over the course of coronary artery disease.
机构信息
Servicio de Cardiología, Instituto de Investigación Sanitaria, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
出版信息
Eur Heart J. 2013 Nov;34(41):3175-81. doi: 10.1093/eurheartj/eht351. Epub 2013 Sep 7.
Abstract
The vascular endothelium regulates blood flow in response to physiological needs. Endothelial dysfunction is closely related to atherosclerosis and its risk factors, and it constitutes an intermediate step on the progression to adverse events throughout the natural history of coronary artery disease (CAD), often affecting clinical outcomes. Understanding the relation of endothelial function with CAD provides an important pathophysiological insight, which can be useful both in clinical and research management. In this review, we summarize the current knowledge on endothelial dysfunction and its prognostic influence throughout the natural history of CAD, from early atherosclerosis to post-transplant management.
摘要
血管内皮细胞根据生理需求调节血流。内皮功能障碍与动脉粥样硬化及其危险因素密切相关，它构成了冠状动脉疾病（CAD）自然病史中向不良事件进展的中间步骤，通常会影响临床结局。了解内皮功能与 CAD 的关系提供了重要的病理生理学见解，这在临床和研究管理中都很有用。在这篇综述中，我们总结了内皮功能障碍及其在 CAD 自然病史中的预后影响的现有知识，涵盖了从早期动脉粥样硬化到移植后管理的各个阶段。
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