• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Rutin exerts antiulcer effect by inhibiting the gastric proton pump.

作者信息

Dubey Shagun, Ganeshpurkar Aditya, Shrivastava Abhishek, Bansal Divya, Dubey Nazneen

机构信息

Drug Discovery Laboratory, Shri Ram Institute of Technology-Pharmacy, Jabalpur, Madhya Pradesh, India.

出版信息

Indian J Pharmacol. 2013 Jul-Aug;45(4):415-7. doi: 10.4103/0253-7613.115011.

DOI:10.4103/0253-7613.115011
PMID:24014928
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3757621/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e05a/3757621/2f1e34d24891/IJPharm-45-415-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e05a/3757621/2f1e34d24891/IJPharm-45-415-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e05a/3757621/2f1e34d24891/IJPharm-45-415-g001.jpg

相似文献

1
Rutin exerts antiulcer effect by inhibiting the gastric proton pump.芦丁通过抑制胃质子泵发挥抗溃疡作用。
Indian J Pharmacol. 2013 Jul-Aug;45(4):415-7. doi: 10.4103/0253-7613.115011.
2
Structure-function relationships in the interaction of amphipathic helical polypeptides with the gastric H/K ATPase.
Ann N Y Acad Sci. 1992 Nov 30;671:443-5. doi: 10.1111/j.1749-6632.1992.tb43824.x.
3
Molecular and cellular regulation of the gastric proton pump.胃质子泵的分子与细胞调控
Biol Pharm Bull. 2004 Jan;27(1):1-12. doi: 10.1248/bpb.27.1.
4
Proton Pump Inhibitors Inhibit Pancreatic Secretion: Role of Gastric and Non-Gastric H+/K+-ATPases.质子泵抑制剂抑制胰腺分泌：胃和非胃H⁺/K⁺-ATP酶的作用
PLoS One. 2015 May 18;10(5):e0126432. doi: 10.1371/journal.pone.0126432. eCollection 2015.
5
Inhibition of gastric H,K-ATPase by new dihydropyrazole derivative KYY-008.新型二氢吡唑衍生物 KYY-008 对胃 H,K-ATP 酶的抑制作用。
Biochem Biophys Res Commun. 2021 Aug 27;567:177-182. doi: 10.1016/j.bbrc.2021.06.056. Epub 2021 Jun 21.
6
Novel 1H-pyrrolo[2,3-c]pyridines as acid pump antagonists (APAs).新型 1H-吡咯并[2,3-c]吡啶类作为酸泵拮抗剂（APAs）。
Bioorg Med Chem Lett. 2010 Sep 1;20(17):5237-40. doi: 10.1016/j.bmcl.2010.06.143. Epub 2010 Jul 23.
7
Studies on antiulcer agents. I. Synthesis and pharmacological properties of ethyl 2-[(1H-benzimidazol-2-yl)sulfinylmethyl]-4-dimethylamino-5- pyrimidinecarboxylate, a new H+/K(+)-ATPase inhibitor possessing mucosal protective activity.抗溃疡药物的研究。I. 2-[(1H-苯并咪唑-2-基)亚磺酰甲基]-4-二甲氨基-5-嘧啶羧酸乙酯的合成及药理性质，一种具有粘膜保护活性的新型H+/K(+)-ATP酶抑制剂
Chem Pharm Bull (Tokyo). 1995 Jan;43(1):166-8. doi: 10.1248/cpb.43.166.
8
Letter: vonoprazan, a long-lasting acid suppressor of the gastric H+, K+-ATPases with - implications for renal H+, K+-ATPases.信函：沃克帕唑，一种长效的胃H⁺，K⁺-ATP酶酸抑制剂及其对肾H⁺，K⁺-ATP酶的影响
Aliment Pharmacol Ther. 2016 Feb;43(3):442-3. doi: 10.1111/apt.13482.
9
Substituted methoxybenzyl-sulfonyl-1H-benzo[d]imidazoles evaluated as effective H/K-ATPase inhibitors and anti-ulcer therapeutics.取代甲氧基苄基-磺酰基-1H-苯并[d]咪唑类化合物被评价为有效的 H/K-ATP 酶抑制剂和抗溃疡治疗药物。
Eur J Med Chem. 2017 Oct 20;139:454-460. doi: 10.1016/j.ejmech.2017.08.001. Epub 2017 Aug 3.
10
Inhibition of gastric H+,K+-ATPase by 4-(2-butyl-6,7-dichloro-2-cyclopentylindan-1-on-5-yl)oxybutyric acid (DCPIB), an inhibitor of volume-regulated anion channel.4-(2-丁基-6,7-二氯-2-环戊基茚满-1-酮-5-基)氧基丁酸（DCPIB）对胃H⁺,K⁺-ATP酶的抑制作用，DCPIB是容积调节性阴离子通道的一种抑制剂
Eur J Pharmacol. 2015 Oct 15;765:34-41. doi: 10.1016/j.ejphar.2015.08.011. Epub 2015 Aug 13.

引用本文的文献

1
Codelivery of Raloxifene and Rutin as PEGylated Nanoliposomes: Formulation, Characterization, and Prophylactic Activity Against Breast Cancer.雷洛昔芬和芦丁作为聚乙二醇化纳米脂质体的共递送：制剂、表征及对乳腺癌的预防活性
Adv Pharm Bull. 2025 Jun 28;15(2):371-389. doi: 10.34172/apb.025.43681. eCollection 2025 Jul.
2
Gastroprotective properties of flavonoid-rich extract of against ethanol-induced gastric ulcer in mice.富含类黄酮的提取物对小鼠乙醇诱导型胃溃疡的胃保护特性。
Heliyon. 2025 Jan 4;11(1):e41625. doi: 10.1016/j.heliyon.2025.e41625. eCollection 2025 Jan 15.
3
Exploring the inhibitory potential of and phytoconstituents against the Spike glycoprotein receptor binding domain of SARS-CoV-2 Delta (B.1.617.2) variant and the main protease (M) as therapeutic candidates, using Molecular docking, DFT, and ADME/Tox studies.

本文引用的文献

1
In vitro H(+) -K(+) ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn.四角乌蔹莓甲醇提取物的体外H(+) -K(+) ATP酶抑制潜力
Pharmacognosy Res. 2012 Apr;4(2):123-6. doi: 10.4103/0974-8490.94738.
2
Endothelium-dependent vasorelaxation effect of rutin-free tartary buckwheat extract in isolated rat thoracic aorta.
J Nutr Biochem. 2008 Oct;19(10):700-7. doi: 10.1016/j.jnutbio.2007.09.005. Epub 2008 Mar 6.
3
Comparative study of flavonoids in experimental models of inflammation.炎症实验模型中黄酮类化合物的比较研究。
利用分子对接、密度泛函理论（DFT）和药物代谢动力学/毒理学（ADME/Tox）研究，探索[具体物质]植物成分对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）Delta（B.1.617.2）变体的刺突糖蛋白受体结合结构域和主要蛋白酶（M）的抑制潜力，以作为治疗候选物。
J Mol Struct. 2022 Sep 5;1263:133032. doi: 10.1016/j.molstruc.2022.133032. Epub 2022 Apr 9.
4
Propolis and Its Gastroprotective Effects on NSAID-Induced Gastric Ulcer Disease: A Systematic Review.蜂胶及其对 NSAID 诱导的胃溃疡疾病的胃保护作用：系统评价。
Nutrients. 2021 Sep 11;13(9):3169. doi: 10.3390/nu13093169.
5
Rutin alleviates cardiomyocyte injury induced by high glucose through inhibiting apoptosis and endoplasmic reticulum stress.芦丁通过抑制细胞凋亡和内质网应激来减轻高糖诱导的心肌细胞损伤。
Exp Ther Med. 2021 Sep;22(3):944. doi: 10.3892/etm.2021.10376. Epub 2021 Jul 1.
6
A Review of the Role of Flavonoids in Peptic Ulcer (2010-2020).黄酮类化合物在消化性溃疡中的作用研究进展（2010-2020）
Molecules. 2020 Nov 20;25(22):5431. doi: 10.3390/molecules25225431.
7
Development and Validation of Conditions for Extracting Flavonoids Content and Evaluation of Antioxidant and Cytoprotective Activities from x Bracteas (var. Rose).x苞片（玫瑰变种）中黄酮类化合物含量提取条件的开发与验证及其抗氧化和细胞保护活性评估
Antioxidants (Basel). 2019 Aug 1;8(8):264. doi: 10.3390/antiox8080264.
8
Growth Performance, Antioxidant Capacity, Lipid-Related Transcript Expression and the Economics of Broiler Chickens Fed Different Levels of Rutin.不同芦丁水平日粮对肉鸡生长性能、抗氧化能力、脂质相关转录本表达及经济效益的影响
Animals (Basel). 2018 Dec 22;9(1):7. doi: 10.3390/ani9010007.
9
Evaluation of traditional medicinal plant, Roxb. (Vitaceae) for antiulcer property.对传统药用植物毛叶葡萄（Roxb.，葡萄科）抗溃疡特性的评估。
Saudi J Biol Sci. 2018 Feb;25(2):293-297. doi: 10.1016/j.sjbs.2017.03.007. Epub 2017 Mar 14.
10
The Pharmacological Potential of Rutin.芦丁的药理潜力
Saudi Pharm J. 2017 Feb;25(2):149-164. doi: 10.1016/j.jsps.2016.04.025. Epub 2016 Apr 30.
Pharmacol Res. 2003 Dec;48(6):601-6. doi: 10.1016/s1043-6618(03)00225-1.
4
The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer.植物类黄酮对哺乳动物细胞的影响：对炎症、心脏病和癌症的意义。
Pharmacol Rev. 2000 Dec;52(4):673-751.
5
Flavonoids: old and new aspects of a class of natural therapeutic drugs.类黄酮：一类天然治疗药物的新老方面
Life Sci. 1999;65(4):337-53. doi: 10.1016/s0024-3205(99)00120-4.
6
Free radical scavenging and antioxidant activity of plant flavonoids.植物类黄酮的自由基清除及抗氧化活性
Adv Exp Med Biol. 1994;366:351-76. doi: 10.1007/978-1-4615-1833-4_25.
7
Gastric cytoprotection.
Scand J Gastroenterol. 1985 Jun;20(5):543-53. doi: 10.3109/00365528509089694.
8
The activity of compounds extracted from feverfew on histamine release from rat mast cells.小白菊提取物对大鼠肥大细胞组胺释放的活性。
J Pharm Pharmacol. 1987 Jun;39(6):466-70. doi: 10.1111/j.2042-7158.1987.tb03421.x.
9
Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia.槲皮素和芦丁作为乙氧甲基甲醇诱导的结肠肿瘤形成的抑制剂。
Carcinogenesis. 1991 Jul;12(7):1193-6. doi: 10.1093/carcin/12.7.1193.
10
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.一种利用蛋白质 - 染料结合原理对微克级蛋白质进行定量的快速灵敏方法。
Anal Biochem. 1976 May 7;72:248-54. doi: 10.1016/0003-2697(76)90527-3.