Davis Margaret A, Moore Danna L, Baker Katherine N K, French Nigel P, Patnode Marianne, Hensley Joni, Macdonald Kathryn, Besser Thomas E
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA.
J Clin Microbiol. 2013 Dec;51(12):3921-7. doi: 10.1128/JCM.01433-13. Epub 2013 Sep 11.
Campylobacteriosis is a frequently reported, food-borne, human bacterial disease that can be associated with ruminant reservoirs, although public health messages primarily focus on poultry. In Washington State, the two counties with the highest concentrations of dairy cattle also report the highest incidences of campylobacteriosis. Conditional logistic regression analysis of case-control data from both counties found living or working on a dairy farm (odds ratio [OR], 6.7 [95% confidence interval [CI], 1.7 to 26.4]) and Hispanic ethnicity (OR, 6.4 [95% CI, 3.1 to 13.1]) to have the strongest significant positive associations with campylobacteriosis. When the analysis was restricted to residents of one county, Hispanic ethnicity (OR, 9.3 [95% CI, 3.9 to 22.2]), contact with cattle (OR, 5.0 [95% CI, 1.3 to 19.5]), and pet ownership (OR, 2.6 [95% CI, 1.1 to 6.3]) were found to be independent risk factors for disease. Campylobacter jejuni isolates from human (n = 65), bovine (n = 28), and retail poultry (n = 27) sources from the same counties were compared using multilocus sequence typing. These results indicated that sequence types commonly found in human isolates were also commonly found in bovine isolates. These findings suggest that, in areas with high concentrations of dairy cattle, exposure to dairy cattle may be more important than food-borne exposure to poultry products as a risk for campylobacteriosis.
弯曲杆菌病是一种经常被报道的食源性人类细菌性疾病，它可能与反刍动物宿主有关，尽管公共卫生信息主要集中在家禽上。在华盛顿州，奶牛集中度最高的两个县弯曲杆菌病发病率也最高。对这两个县的病例对照数据进行条件逻辑回归分析发现，在奶牛场生活或工作（优势比[OR]为6.7[95%置信区间[CI]为1.7至26.4]）以及西班牙裔（OR为6.4[95%CI为3.1至13.1]）与弯曲杆菌病有最强的显著正相关。当分析仅限于一个县的居民时，发现西班牙裔（OR为9.3[95%CI为3.9至22.2]）、与牛接触（OR为5.0[95%CI为1.3至19.5]）以及拥有宠物（OR为2.6[95%CI为1.1至6.3]）是疾病的独立危险因素。使用多位点序列分型对来自同一县的人类（n = 65）、牛（n = 28）和零售家禽（n = 27）来源的空肠弯曲菌分离株进行了比较。这些结果表明，在人类分离株中常见的序列类型在牛分离株中也很常见。这些发现表明，在奶牛集中度高的地区，作为弯曲杆菌病的一个风险因素，接触奶牛可能比通过食物接触家禽产品更为重要。
