Davis Stephen C, Li Jie, Gil Joel, Valdes Jose, Solis Michael, Treu Ryan, Kirnser Robert S
Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL,, USA.
Int Wound J. 2015 Oct;12(5):510-6. doi: 10.1111/iwj.12144. Epub 2013 Sep 13.
The concept that undisturbed wound healing, optimised by dressing choice, improves wound outcomes has become a focal point of consideration when evaluating wound management regimens in recent years. However, little evidence exists related to wound contact layers and the potential detrimental effects of the intimate contact with the wound bed. The aim of this study was to evaluate the effects of atraumatic wound contact dressings on the healing of partial-thickness wounds in comparison to untreated air-exposed wounds. Using an in vivo porcine wound model the handling properties of each dressing in terms of adhesion were analysed. Methods of wound characterisation included histological analysis of granulation tissue formation and epithelialisation and this was correlated with various clinical observations. Differences were found between dressings in terms of adherence to the wound bed and surrounding skin, capacity to retain wound exudates and enhancement of healing.
近年来，在评估伤口处理方案时，通过选择敷料优化的无干扰伤口愈合可改善伤口预后这一概念已成为考虑的焦点。然而，关于伤口接触层以及与伤口床密切接触的潜在有害影响的证据很少。本研究的目的是评估与未处理的暴露于空气中的伤口相比，无创伤性伤口接触敷料对部分厚度伤口愈合的影响。使用体内猪伤口模型，分析了每种敷料在粘附方面的处理特性。伤口特征化方法包括对肉芽组织形成和上皮形成的组织学分析，并将其与各种临床观察结果相关联。在敷料对伤口床和周围皮肤的粘附性、保留伤口渗出物的能力以及促进愈合方面发现了差异。
