Laboratório Nacional Agropecuário, Ministério da Agricultura, Pecuária e Abastecimento , Pedro Leopoldo, MG , Brasil.
Braz J Microbiol. 2012 Oct;43(4):1632-40. doi: 10.1590/S1517-838220120004000048. Epub 2012 Jun 1.
Suid herpesvirus 1 (SuHV-1) is the causative agent of pseudorabies (PR), a disease of great importance due to the huge losses it causes in the swine industry. The aim of this study was to determine a method for genotyping SuHV-1 based on partial sequences of the gene coding for glycoprotein C (gC) and to elucidate the possible reasons for the variability of this region. A total of 109 gCsequences collected from GenBank were divided into five major groups after reconstruction of a phylogenetic tree by Bayesian inference. The analysis showed that a portion of gC (approximately 671 bp) is under selective pressure at various points that coincide with regions of protein disorder. It was also possible to divide SuHV-1 into five genotypes that evolved under different selective pressures. These genotypes are not specific to countries or continents, perhaps due to multiple introduction events related to the importation of swine.
猪疱疹病毒 1 型（SuHV-1）是伪狂犬病（PR）的病原体，由于其给养猪业造成巨大损失，因此具有重要意义。本研究旨在确定一种基于糖蛋白 C（gC）编码基因部分序列的 SuHV-1 基因分型方法，并阐明该区域变异的可能原因。通过贝叶斯推断重建系统发育树后，将从 GenBank 中收集的 109 个 gC 序列分为五个主要组。分析表明，gC 的一部分（约 671bp）在不同的点受到选择压力，这些点与蛋白质无序区域重合。也有可能将 SuHV-1 分为五个在不同选择压力下进化的基因型。这些基因型与国家或大洲无关，可能是由于与猪的进口有关的多次传入事件所致。
