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阳极氧化钛表面的表面特性与生物活性

Surface characteristics and bioactivity of an anodized titanium surface.

作者信息

Kim Kyul, Lee Bo-Ah, Piao Xing-Hui, Chung Hyun-Ju, Kim Young-Joon

机构信息

Department of Periodontology, Dental Research Institute, Chonnam National University School of Dentistry, Gwangju, Korea.

出版信息

J Periodontal Implant Sci. 2013 Aug;43(4):198-205. doi: 10.5051/jpis.2013.43.4.198. Epub 2013 Aug 31.

DOI:10.5051/jpis.2013.43.4.198
PMID:24040573
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3769599/
Abstract

PURPOSE

The aim of this study was to evaluate the surface properties and biological response of an anodized titanium surface by cell proliferation and alkaline phosphatase activity analysis.

METHODS

Commercial pure titanium (Ti) disks were prepared. The samples were divided into an untreated machined Ti group and anodized Ti group. The anodization of cp-Ti was formed using a constant voltage of 270 V for 60 seconds. The surface properties were evaluated using scanning electron microscopy, X-ray photoelectron spectroscopy, and an image analyzing microscope. The surface roughness was evaluated by atomic force microscopy and a profilometer. The contact angle and surface energy were analyzed. Cell adhesion, cell proliferation, and alkaline phosphatase activity were evaluated using mouse MC3T3-E1 cells.

RESULTS

The anodized Ti group had a more porous and thicker layer on its surface. The surface roughness of the two groups measured by the profilometer showed no significant difference (P>0.001). The anodized Ti dioxide (TiO2) surface exhibited better corrosion resistance and showed a significantly lower contact angle than the machined Ti surface (P>0.001). Although there was no significant difference in the cell viability between the two groups (P>0.001), the anodized TiO2 surface showed significantly enhanced alkaline phosphatase activity (P<0.001).

CONCLUSIONS

These results suggest that the surface modification of Ti by anodic oxidation improved the osteogenic response of the osteoblast cells.

摘要

目的

本研究旨在通过细胞增殖和碱性磷酸酶活性分析来评估阳极氧化钛表面的性能及生物学反应。

方法

制备商业纯钛（Ti）圆盘。将样品分为未处理的机械加工Ti组和阳极氧化Ti组。采用270 V恒压60秒对cp-Ti进行阳极氧化处理。使用扫描电子显微镜、X射线光电子能谱和图像分析显微镜评估表面性能。通过原子力显微镜和轮廓仪评估表面粗糙度。分析接触角和表面能。使用小鼠MC3T3-E1细胞评估细胞黏附、细胞增殖和碱性磷酸酶活性。

结果

阳极氧化Ti组表面有更多孔且更厚的层。轮廓仪测量的两组表面粗糙度无显著差异（P>0.001）。阳极氧化二氧化钛（TiO2）表面表现出更好的耐腐蚀性，且接触角显著低于机械加工Ti表面（P>0.001）。尽管两组细胞活力无显著差异（P>0.001），但阳极氧化TiO2表面的碱性磷酸酶活性显著增强（P<0.001）。

结论

这些结果表明，通过阳极氧化对Ti进行表面改性可改善成骨细胞的成骨反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a8/3769599/96e82ec9875b/jpis-43-198-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a8/3769599/0934d52eee97/jpis-43-198-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a8/3769599/c4ad2bbc3ec2/jpis-43-198-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a8/3769599/2708b48c2333/jpis-43-198-g003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a8/3769599/77d46b923826/jpis-43-198-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a8/3769599/e65e9802f341/jpis-43-198-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a8/3769599/1de2714faf34/jpis-43-198-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a8/3769599/1993e156b0ef/jpis-43-198-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a8/3769599/96e82ec9875b/jpis-43-198-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a8/3769599/0934d52eee97/jpis-43-198-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a8/3769599/c4ad2bbc3ec2/jpis-43-198-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a8/3769599/2708b48c2333/jpis-43-198-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a8/3769599/7ac57bf246ca/jpis-43-198-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a8/3769599/77d46b923826/jpis-43-198-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a8/3769599/e65e9802f341/jpis-43-198-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a8/3769599/1de2714faf34/jpis-43-198-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a8/3769599/1993e156b0ef/jpis-43-198-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a8/3769599/96e82ec9875b/jpis-43-198-g009.jpg

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