Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, Gravendijkwal 230, NL3015 CE Rotterdam, Netherlands.
Nat Rev Gastroenterol Hepatol. 2013 Dec;10(12):741-5. doi: 10.1038/nrgastro.2013.178. Epub 2013 Sep 17.
The evidence for a strong correlation between the gut microbiota and colorectal carcinogenesis is quickly gathering pace. This correlation raises important questions, such as whether analysis of the microbiota can be used for screening purposes, and whether targeted intervention can influence the risk of development and progression of neoplasia. The recovery of several pathobionts-such as members of the different bacterial phyla Proteobacteria, Bacteroidetes and Fusobacteria-from the tumour microenvironment of patients with colorectal cancer (CRC) now provides a link between specific microbial colonization and cancer. However, other intestinal bacteria belonging to another major intestinal phylum, Firmicutes, might be effective in the treatment of pathogenic inflammation related to CRC. Future approaches based on the analysis of the gut microbiota of patients with CRC combined with large human cohort studies might open up new possibilities for further prophylactic, screening and treatment strategies.
肠道微生物群与结直肠癌发生之间存在强相关性的证据正在迅速积累。这种相关性提出了一些重要的问题，例如是否可以分析微生物群来进行筛查，以及靶向干预是否可以影响肿瘤发生和发展的风险。从结直肠癌（CRC）患者的肿瘤微环境中恢复了几种条件致病菌，例如不同细菌门（变形菌门、拟杆菌门和梭杆菌门）的成员，为特定微生物定植与癌症之间提供了联系。然而，属于另一个主要肠道菌门（Firmicutes）的其他肠道细菌可能对与 CRC 相关的致病性炎症有效。基于对 CRC 患者肠道微生物群的分析并结合大型人群队列研究的未来方法可能为进一步的预防、筛查和治疗策略开辟新的可能性。
