Pirozzi K L, Long C J, McAleer C W, Smith A S T, Hickman J J
NanoScience Technology Center, University of Central Florida, 12424 Research Parkway, Orlando, Florida 32826, USA.
Appl Phys Lett. 2013 Aug 19;103(8):83108. doi: 10.1063/1.4817939. Epub 2013 Aug 20.
Rigorous analysis of muscle function in systems is needed for both acute and chronic biomedical applications. Forces generated by skeletal myotubes on bio-microelectromechanical cantilevers were calculated using a modified version of Stoney's thin-film equation and finite element analysis (FEA), then analyzed for regression to physical parameters. The Stoney's equation results closely matched the more intensive FEA and the force correlated to cross-sectional area (CSA). Normalizing force to measured CSA significantly improved the statistical sensitivity and now allows for close comparison of data to measurements for applications in exercise physiology, robotics, and modeling neuromuscular diseases.
对于急性和慢性生物医学应用而言，都需要对系统中的肌肉功能进行严格分析。利用修正版的斯托尼薄膜方程和有限元分析（FEA）计算骨骼肌管在生物微机电悬臂上产生的力，然后分析其与物理参数的回归关系。斯托尼方程的结果与更精细的有限元分析结果非常匹配，且该力与横截面积（CSA）相关。将力归一化到测量的横截面积显著提高了统计灵敏度，现在可以将数据与运动生理学、机器人技术和神经肌肉疾病建模应用中的测量值进行密切比较。
