Du T, Sun X, Huo R, Yu X
Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Anesthesiology, School of Stomatology, Fourth Military Medical University, Xi'an, China.
Int J Obes (Lond). 2014 Jun;38(6):840-7. doi: 10.1038/ijo.2013.181. Epub 2013 Sep 19.
The visceral adiposity index (VAI) and hypertriglyceridemic waist phenotype (the simultaneous presence of waist circumference (WC)≥90/80 cm for men/women and plasma triglyceride (TG) concentration ≥1.7 mmol l(-1) for both genders) have been identified as good indicators of visceral adiposity, which is an independent risk factor for diabetes. The Chinese population is characterized by a predominance of visceral fat accumulation despite having comparatively low weight. These two surrogate markers of visceral adiposity might effectively identify Chinese adults who are at risk of getting diabetes. We aimed to examine the association between VAI and risk of diabetes or between the hypertriglyceridemic waist phenotype and diabetes risk.
We conducted a cross-sectional analysis of 7639 Chinese men and women aged ≥18 years using data from the China Health and Nutrition Survey 2009. Logistic regression was used to evaluate the associations.
For men, compared with participants in the lowest quartile of VAI scores, the multivariable-adjusted odds ratios (ORs) (with 95% confidence intervals) for diagnosed diabetes were 1.1 (0.7-1.7), 1.9 (1.3-2.8) and 3.6 (2.5-5.3) for those in the second, third, and top quartile of VAI scores, respectively. For women, the corresponding figures were 0.9 (0.5-1.4), 1.7 (1.1-2.6) and 2.8 (1.9-4.2), respectively. The multivariate-adjusted ORs (with 95% confidence intervals) for diabetes in men with the hypertriglyceridemic waist phenotype compared with men with both WC and TG measurements below the defined cut points were 3.7 (2.6-5.4). For women, the corresponding figure was 3.7 (2.4-5.5). For both men and women, the associations between the 4th quartile of VAI scores and risk of diabetes or between the hypertriglyceridemic waist phenotype and risk of diabetes were consistently seen in various subgroups.
Among Chinese adults, high VAI scores and the hypertriglyceridemic waist phenotype are strongly associated with diabetes risk.
内脏脂肪指数（VAI）和高甘油三酯血症腰围表型（男性腰围（WC）≥90cm/女性腰围≥80cm，且男女血浆甘油三酯（TG）浓度均≥1.7mmol/L）已被确定为内脏脂肪的良好指标，内脏脂肪是糖尿病的独立危险因素。中国人群的特点是尽管体重相对较低，但内脏脂肪堆积占主导。这两种内脏脂肪的替代标志物可能有效地识别有患糖尿病风险的中国成年人。我们旨在研究VAI与糖尿病风险之间的关联，或高甘油三酯血症腰围表型与糖尿病风险之间的关联。
我们使用2009年中国健康与营养调查的数据，对7639名年龄≥18岁的中国男性和女性进行了横断面分析。采用逻辑回归评估关联。
对于男性，与VAI得分处于最低四分位数的参与者相比，VAI得分处于第二、第三和最高四分位数的参与者患糖尿病的多变量调整比值比（OR）（及其95%置信区间）分别为1.1（0.7-1.7）、1.9（1.3-2.8）和3.6（2.5-5.3）。对于女性，相应数字分别为0.9（0.5-1.4）、1.7（1.1-2.6）和2.8（1.9-4.2）。与WC和TG测量值均低于定义切点的男性相比，具有高甘油三酯血症腰围表型的男性患糖尿病的多变量调整OR（及其95%置信区间）为3.7（2.6-5.4）。对于女性，相应数字为3.7（2.4-5.5）。对于男性和女性，在各个亚组中均一致观察到VAI得分第四四分位数与糖尿病风险之间的关联，或高甘油三酯血症腰围表型与糖尿病风险之间的关联。
在中国成年人中，高VAI得分和高甘油三酯血症腰围表型与糖尿病风险密切相关。
