具有光学变焦功能的双模态内镜显微镜。
Dual modality endomicroscope with optical zoom capability.
作者信息
Ouzounov Dimitre G, Rivera David R, Williams Wendy O, Stupinski John A, Southard Teresa L, Hume Kelly H, Bentley Julie, Weiss Robert S, Webb Watt W, Xu Chris
机构信息
Schol of Applied and Engineering Physics, Cornell University, Ithaca, NY, 14853, USA.
出版信息
Biomed Opt Express. 2013 Aug 1;4(9):1494-503. doi: 10.1364/BOE.4.001494. eCollection 2013.
Abstract
We present a miniature endomicroscope that combines large field-of-view (FOV) (1.15 mm) reflectance imaging with high-resolution (~0.5 μm) multiphoton intrinsic fluorescence imaging. We acquired in vivo and ex vivo images of unstained normal and tumor-laden tissues by using the large-FOV mode to navigate to the site of interest and then switching to the high-resolution modality to resolve cellular details.
摘要
我们展示了一种微型内窥镜，它将大视野（1.15毫米）反射成像与高分辨率（约0.5微米）多光子固有荧光成像相结合。我们通过使用大视野模式导航到感兴趣的部位，然后切换到高分辨率模式以解析细胞细节，获取了未染色的正常组织和肿瘤组织的体内和体外图像。
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