Section of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, N-0316 Oslo, Norway.
Molecules. 2013 Aug 26;18(9):10312-9. doi: 10.3390/molecules180910312.
Three flavone-C-glycosides-cassiaoccidentalin A (1), isovitexin (2) and isoorientin (3)-were isolated from the ethyl acetate (EtOAc) soluble fraction of the methanol crude extract of the African medicinal plant Biophytum umbraculum, This is the first report of these compounds in this plant. All compounds were identified by spectroscopic analysis and comparison with published data. Isoorientin (3) and the EtOAc extract showed the greatest antioxidant activity in the DPPH assay as well as the strongest inhibition of xanthine oxidase (XO) and 15-lipoxygenase (15-LO). From these results, the extract of B. umbraculum might be a valuable source of flavone C-glycosides.
从非洲药用植物 Biophytum umbraculum 的甲醇粗提物的乙酸乙酯（EtOAc）可溶部分中分离得到三种黄酮 C-糖苷-桂皮酸 A（1）、异荭草苷（2）和异芦丁（3）。这是这些化合物在该植物中的首次报道。所有化合物均通过光谱分析和与已发表数据的比较进行了鉴定。异芦丁（3）和 EtOAc 提取物在 DPPH 测定中表现出最强的抗氧化活性，以及对黄嘌呤氧化酶（XO）和 15-脂氧合酶（15-LO）的最强抑制作用。根据这些结果，B. umbraculum 的提取物可能是黄酮 C-糖苷的有价值来源。
