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Cross-seeding of misfolded proteins: implications for etiology and pathogenesis of protein misfolding diseases.

作者信息

Morales Rodrigo, Moreno-Gonzalez Ines, Soto Claudio

机构信息

Mitchell Center for Alzheimer's Disease and Related Brain Disorders, Department of Neurology, University of Texas Houston Medical School, Houston, Texas, United States of America.

出版信息

PLoS Pathog. 2013 Sep;9(9):e1003537. doi: 10.1371/journal.ppat.1003537. Epub 2013 Sep 19.

DOI:10.1371/journal.ppat.1003537
PMID:24068917
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3777858/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4836/3777858/996567b3fed8/ppat.1003537.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4836/3777858/996567b3fed8/ppat.1003537.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4836/3777858/996567b3fed8/ppat.1003537.g001.jpg

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Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders.阿尔茨海默病和其他神经退行性疾病中的致病蛋白播种。
Ann Neurol. 2011 Oct;70(4):532-40. doi: 10.1002/ana.22615.
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The projected effect of risk factor reduction on Alzheimer's disease prevalence.预估危险因素降低对阿尔茨海默病患病率的影响。
作为肌萎缩侧索硬化症潜在治疗方法的超氧化物歧化酶1突变体感染性抑制剂的计算搜索
Int J Mol Sci. 2025 May 13;26(10):4660. doi: 10.3390/ijms26104660.
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Experimental methods for studying amyloid cross-interactions.研究淀粉样蛋白交叉相互作用的实验方法。
Protein Sci. 2025 Jun;34(6):e70151. doi: 10.1002/pro.70151.
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Microglia-driven inflammation induces progressive tauopathies and synucleinopathies.小胶质细胞驱动的炎症会诱发进行性tau蛋白病和α-突触核蛋白病。
Exp Mol Med. 2025 May 1. doi: 10.1038/s12276-025-01450-z.
6
Aggregatin is a mitochondrial regulator of MAVS activation to drive innate immunity.凝集素是一种线粒体调节因子,可激活MAVS以驱动先天免疫。
J Immunol. 2025 Feb 1;214(2):238-252. doi: 10.1093/jimmun/vkae019.
7
The p3 peptides (Aβ) rapidly form amyloid fibrils that cross-seed with full-length Aβ.p3肽(Aβ)迅速形成淀粉样原纤维,这些原纤维会与全长Aβ发生交叉播种。
Nat Commun. 2025 Feb 27;16(1):2040. doi: 10.1038/s41467-025-57341-4.
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