Department of Epidemiology, University of Washington, Seattle, WA, USA.
Atherosclerosis. 2013 Oct;230(2):278-83. doi: 10.1016/j.atherosclerosis.2013.07.045. Epub 2013 Aug 2.
Both coronary artery calcification (CAC) and the ankle brachial index (ABI) are measures of subclinical atherosclerotic disease. The influence of physical activity on the longitudinal change in these measures remains unclear. To assess this relation we examined the association between these measures and self-reported physical activity in the Multi-Ethnic Study of Atherosclerosis (MESA).
At baseline, the MESA participants were free of clinically evident cardiovascular disease. We included all participants with an ABI between 0.90 and 1.40 (n = 5656). Predictor variables were based on self-reported measures with physical activity being assessed using the Typical Week Physical Activity Survey from which metabolic equivalent-minutes/week of activity were calculated. We focused on physical activity intensity, intentional exercise, sedentary behavior, and conditioning. Incident peripheral artery disease (PAD) was defined as the progression of ABI to values below 0.90 (given the baseline range of 0.90-1.40). Incident CAC was defined as a CAC score >0 Agatston units upon follow up with a baseline score of 0 Agatston units.
Mean age of participants was 61 years, 53% were female, and mean body mass index was 28 kg/m(2). After adjusting for traditional cardiovascular risk factors and socioeconomic factors, intentional exercise was protective for incident peripheral artery disease (Relative Risk (RR) = 0.85, 95% Confidence Interval (CI): 0.74-0.98). After adjusting for traditional cardiovascular risk factors and socioeconomic factors, there was a significant association between vigorous PA and incident CAC (RR = 0.97, 95% CI: 0.94-1.00). There was also a significant association between sedentary behavior and increased amount of CAC among participants with CAC at baseline (Δlog (Agatston Units + 25) = 0.027, 95% CI 0.002, 0.052).
These data suggest that there is an association between physical activity/sedentary behavior and the progression of two different measures of subclinical atherosclerotic disease.
冠状动脉钙化（CAC）和踝臂指数（ABI）均是亚临床动脉粥样硬化疾病的指标。运动对这些指标的纵向变化的影响尚不清楚。为了评估这种关系，我们在动脉粥样硬化多民族研究（MESA）中检查了这些指标与自我报告的体力活动之间的关联。
在基线时，MESA 参与者没有临床明显的心血管疾病。我们纳入了 ABI 为 0.90 至 1.40 之间的所有参与者（n=5656）。预测变量基于自我报告的指标，通过典型周体力活动调查来评估体力活动，其中计算了代谢当量分钟/周的活动量。我们重点关注体力活动强度、有意锻炼、久坐行为和调节。外周动脉疾病（PAD）的发生定义为 ABI 下降到低于 0.90 的值（考虑到基线范围为 0.90-1.40）。CAC 事件定义为随访时 CAC 评分>0 个 Agatston 单位，且基线时 CAC 评分为 0 个 Agatston 单位。
参与者的平均年龄为 61 岁，53%为女性，平均体重指数为 28kg/m2。在调整传统心血管危险因素和社会经济因素后，有意锻炼对 PAD 的发生具有保护作用（相对风险（RR）=0.85，95%置信区间（CI）：0.74-0.98）。在调整传统心血管危险因素和社会经济因素后，剧烈 PA 与 CAC 事件之间存在显著关联（RR=0.97，95%CI：0.94-1.00）。在基线时存在 CAC 的参与者中，久坐行为与 CAC 量的增加之间也存在显著关联（Δlog（Agatston 单位+25）=0.027，95%CI 0.002，0.052）。
这些数据表明，体力活动/久坐行为与两种不同的亚临床动脉粥样硬化疾病指标的进展之间存在关联。
