Dedovic Katarina, Duchesne Annie, Engert Veronika, Lue Sonja Damika, Andrews Julie, Efanov Simona I, Beaudry Thomas, Pruessner Jens C
Social and Affective Neuroscience Laboratory, Psychology Department, University of California, Los Angeles, CA 90095, USA, Douglas Mental Health University Institute, Integrated Program in Neuroscience, Department of Psychiatry, McGill University, Montreal, QC H4H 1R2, Canada, Maxplanck Institute, 04103 Leipzig, Germany, American School of professional Psychology, Washington, DC 22209, USA, and McGill Centre for Studies in Aging, Faculty of Medicine, McGill University, Montreal, QC H4H 1R2, Canada
Social and Affective Neuroscience Laboratory, Psychology Department, University of California, Los Angeles, CA 90095, USA, Douglas Mental Health University Institute, Integrated Program in Neuroscience, Department of Psychiatry, McGill University, Montreal, QC H4H 1R2, Canada, Maxplanck Institute, 04103 Leipzig, Germany, American School of professional Psychology, Washington, DC 22209, USA, and McGill Centre for Studies in Aging, Faculty of Medicine, McGill University, Montreal, QC H4H 1R2, Canada.
Soc Cogn Affect Neurosci. 2014 Oct;9(10):1632-44. doi: 10.1093/scan/nst151. Epub 2013 Sep 26.
This study aimed to identify vulnerability patterns in psychological, physiological and neural responses to mild psychosocial challenge in a population that is at a direct risk of developing depression, but who has not as yet succumbed to the full clinical syndrome. A group of healthy and a group of subclinically depressed participants underwent a modified Montreal Imaging Stress task (MIST), a mild neuroimaging psychosocial task and completed state self-esteem and mood measures. Cortisol levels were assessed throughout the session. All participants showed a decrease in performance self-esteem levels following the MIST. Yet, the decline in performance self-esteem levels was associated with increased levels of anxiety and confusion in the healthy group, but increased levels of depression in the subclinical group, following the MIST. The subclinical group showed overall lower cortisol levels compared with the healthy group. The degree of change in activity in the subgenual anterior cingulate cortex in response to negative evaluation was associated with increased levels of depression in the whole sample. Findings suggest that even in response to a mild psychosocial challenge, those individuals vulnerable to depression already show important maladaptive response patterns at psychological and neural levels. The findings point to important targets for future interventions.
本研究旨在确定在直接面临患抑郁症风险但尚未出现完全临床综合征的人群中，对轻度心理社会挑战的心理、生理和神经反应的脆弱性模式。一组健康参与者和一组亚临床抑郁症参与者接受了改良的蒙特利尔成像应激任务（MIST），这是一项轻度神经成像心理社会任务，并完成了状态自尊和情绪测量。在整个过程中评估皮质醇水平。所有参与者在MIST后表现自尊水平均下降。然而，在MIST后，健康组中表现自尊水平的下降与焦虑和困惑水平的增加有关，而亚临床组中则与抑郁水平的增加有关。与健康组相比，亚临床组的皮质醇水平总体较低。膝下前扣带回皮质对负面评价的活动变化程度与整个样本中的抑郁水平增加有关。研究结果表明，即使是对轻度心理社会挑战的反应，那些易患抑郁症的个体在心理和神经层面已经表现出重要的适应不良反应模式。这些发现指出了未来干预的重要目标。
