Department of Medicine, University of Toronto School of Medicine, Toronto, Ontario, Canada; Mediprobe Research, Inc., London, Ontario, Canada.
Clin Dermatol. 2013 Sep-Oct;31(5):544-54. doi: 10.1016/j.clindermatol.2013.06.011.
Onychomycosis treatments include nail avulsion and debridement by chemical or surgical procedures, topical and oral antifungals, and device-based therapies. The advantages, disadvantages, and limitations of the different types of treatments--including the most commonly prescribed topical (ciclopirox) and oral (terbinafine, itraconazole, and fluconazole) treatments for onychomycosis caused by dermatophytes, non-dermatophyte molds, and yeasts--are reviewed. Safety and efficacy data for the healthy adult population and for special populations such as children and diabetic patients have confirmed the importance of proper mycological diagnosis before the initiation of therapy as well as the evaluation of the risks and benefits of the different treatments.
甲真菌病的治疗方法包括拔甲和化学或手术清创、局部和口服抗真菌药物以及器械治疗。本文回顾了不同类型治疗方法的优缺点和局限性，包括最常开处方的治疗皮肤癣菌、非皮肤癣菌霉菌和酵母菌所致甲真菌病的局部药物（环吡酮）和口服药物（特比萘芬、伊曲康唑和氟康唑）。健康成年人以及儿童和糖尿病患者等特殊人群的安全性和疗效数据证实，在开始治疗前进行正确的真菌学诊断以及评估不同治疗方法的风险和益处非常重要。
