生物物理定义和细胞相容的共价适应性网络作为粘弹性 3D 细胞培养系统。
Biophysically defined and cytocompatible covalently adaptable networks as viscoelastic 3D cell culture systems.
机构信息
Department of Chemical and Biological Engineering, University of Colorado Boulder, Jennie Smoly Caruthers Biotechnology Building, 3415 Colorado Ave, 596 UCB, Boulder, CO, 80303; BioFrontiers Institute, University of Colorado Boulder, Jennie Smoly Caruthers Biotechnology Building, 3415 Colorado Ave, 596 UCB, Boulder, CO, 80303.
出版信息
Adv Mater. 2014 Feb 12;26(6):865-72. doi: 10.1002/adma.201303680. Epub 2013 Oct 11.
Abstract
Presented here is a cytocompatible covalently adaptable hydrogel uniquely capable of mimicking the complex biophysical properties of native tissue and enabling natural cell functions without matrix degradation. Demonstrated is both the ability to control elastic modulus and stress relaxation time constants by more than an order of magnitude while predicting these values based on fundamental theoretical understanding and the simulation of muscle tissue and the encapsulation of myoblasts.
摘要
这里呈现的是一种细胞相容的、可共价适应的水凝胶，具有独特的能力，可以模拟天然组织的复杂生物物理特性，并在不降解基质的情况下实现自然细胞功能。我们展示了不仅能够通过一个数量级以上来控制弹性模量和应力松弛时间常数，而且还能够基于基本理论理解和肌肉组织模拟来预测这些值，同时还展示了对成肌细胞的包封。
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