黄烷酮：新兴的药用查尔酮。
The flavokawains: uprising medicinal chalcones.
机构信息
Bright Sparks Unit, University Malaya, 53500, Kuala Lumpur, Malaysia.
出版信息
Cancer Cell Int. 2013 Oct 22;13(1):102. doi: 10.1186/1475-2867-13-102.
Abstract
Plant-based compounds have been in the spotlight in search of new and promising drugs. Flavokawain A, B and C are naturally occurring chalcones that have been isolated from several medicinal plants; namely the piper methysticum or commercially known as the kava-kava. Multiple researches have been done to evaluate the bioactivities of these compounds. It has been shown that all three flavokawains may hold promising anti-cancer effects. It has also been revealed that both flavokawain A and B are involved in the induction of cell cycle arrest in several cancer cell lines. Nevertheless, flavokawain B was shown to be more effective in treating in vitro cancer cell lines as compared to flavokawain A and C. Flavokawain B also exerts antinociceptive effects as well as anti-inflammation properties. This mini-review attempts to discuss the biological properties of all the flavokawains that have been reported.
摘要
植物化合物一直是寻找新的、有前途的药物的焦点。黄烷酮 A、B 和 C 是天然存在的查耳酮，已从几种药用植物中分离出来；即胡椒 methysticum 或商业上称为卡瓦卡瓦。已经进行了多项研究来评估这些化合物的生物活性。研究表明，这三种黄烷酮可能具有有前途的抗癌作用。研究还表明，黄烷酮 A 和 B 都参与了几种癌细胞系的细胞周期阻滞诱导。然而，与黄烷酮 A 和 C 相比，黄烷酮 B 被证明在治疗体外癌细胞系方面更有效。黄烷酮 B 还具有镇痛作用和抗炎特性。本综述试图讨论已报道的所有黄烷酮的生物学特性。
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本文引用的文献
1
Flavokawain B, a kava chalcone, inhibits growth of human osteosarcoma cells through G2/M cell cycle arrest and apoptosis.黄烷酮 B，一种卡瓦胡椒查尔酮，通过 G2/M 细胞周期阻滞和细胞凋亡抑制人骨肉瘤细胞的生长。
Mol Cancer. 2013 Jun 10;12:55. doi: 10.1186/1476-4598-12-55.
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Suppression of iNOS and COX-2 expression by flavokawain A via blockade of NF-κB and AP-1 activation in RAW 264.7 macrophages. flavokawain A 通过阻断 NF-κB 和 AP-1 激活抑制 RAW 264.7 巨噬细胞中 iNOS 和 COX-2 的表达。
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Flavokawain B induces apoptosis of non-small cell lung cancer H460 cells via Bax-initiated mitochondrial and JNK pathway. flavokawain B 通过 Bax 起始的线粒体和 JNK 途径诱导非小细胞肺癌 H460 细胞凋亡。
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Multispectroscopic and molecular modeling approach to investigate the interaction of flavokawain B with human serum albumin.采用多光谱和分子建模方法研究 flavokawain B 与人血清白蛋白的相互作用。
J Agric Food Chem. 2012 Jun 13;60(23):5899-908. doi: 10.1021/jf301139h. Epub 2012 Jun 4.
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Flavokawain B, a novel, naturally occurring chalcone, exhibits robust apoptotic effects and induces G2/M arrest of a uterine leiomyosarcoma cell line.黄樟素B是一种新型的天然查尔酮，具有强大的凋亡作用，并能诱导子宫平滑肌肉瘤细胞系发生G2/M期阻滞。
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Kava components down-regulate expression of AR and AR splice variants and reduce growth in patient-derived prostate cancer xenografts in mice.卡瓦成分下调 AR 和 AR 剪接变异体的表达，并减少小鼠来源的前列腺癌异种移植瘤的生长。
PLoS One. 2012;7(2):e31213. doi: 10.1371/journal.pone.0031213. Epub 2012 Feb 9.
7
The chalcone flavokawain B induces G2/M cell-cycle arrest and apoptosis in human oral carcinoma HSC-3 cells through the intracellular ROS generation and downregulation of the Akt/p38 MAPK signaling pathway.查尔酮 flavokawain B 通过细胞内 ROS 的产生和下调 Akt/p38 MAPK 信号通路诱导人口腔鳞癌细胞 HSC-3 的 G2/M 期细胞周期阻滞和凋亡。
J Agric Food Chem. 2012 Mar 7;60(9):2385-97. doi: 10.1021/jf205053r. Epub 2012 Feb 27.
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Flavokawain B induces apoptosis of human oral adenoid cystic cancer ACC-2 cells via up-regulation of Bim and down-regulation of Bcl-2 expression.黄樟素B通过上调Bim和下调Bcl-2表达诱导人涎腺腺样囊性癌ACC-2细胞凋亡。
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Flavokawain B inhibits growth of human squamous carcinoma cells: Involvement of apoptosis and cell cycle dysregulation in vitro and in vivo.Flavokawain B 抑制人鳞状细胞癌细胞的生长：体外和体内的细胞凋亡和细胞周期失调的参与。
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