Bright Sparks Unit, University Malaya, 53500, Kuala Lumpur, Malaysia.
Cancer Cell Int. 2013 Oct 22;13(1):102. doi: 10.1186/1475-2867-13-102.
Plant-based compounds have been in the spotlight in search of new and promising drugs. Flavokawain A, B and C are naturally occurring chalcones that have been isolated from several medicinal plants; namely the piper methysticum or commercially known as the kava-kava. Multiple researches have been done to evaluate the bioactivities of these compounds. It has been shown that all three flavokawains may hold promising anti-cancer effects. It has also been revealed that both flavokawain A and B are involved in the induction of cell cycle arrest in several cancer cell lines. Nevertheless, flavokawain B was shown to be more effective in treating in vitro cancer cell lines as compared to flavokawain A and C. Flavokawain B also exerts antinociceptive effects as well as anti-inflammation properties. This mini-review attempts to discuss the biological properties of all the flavokawains that have been reported.
植物化合物一直是寻找新的、有前途的药物的焦点。黄烷酮 A、B 和 C 是天然存在的查耳酮，已从几种药用植物中分离出来；即胡椒 methysticum 或商业上称为卡瓦卡瓦。已经进行了多项研究来评估这些化合物的生物活性。研究表明，这三种黄烷酮可能具有有前途的抗癌作用。研究还表明，黄烷酮 A 和 B 都参与了几种癌细胞系的细胞周期阻滞诱导。然而，与黄烷酮 A 和 C 相比，黄烷酮 B 被证明在治疗体外癌细胞系方面更有效。黄烷酮 B 还具有镇痛作用和抗炎特性。本综述试图讨论已报道的所有黄烷酮的生物学特性。
