Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Psychiatry Res. 2013 Dec 30;214(3):331-40. doi: 10.1016/j.pscychresns.2013.07.004. Epub 2013 Oct 19.
Adults recovered from Anorexia nervosa (AN) have altered reward modulation within striatal limbic regions associated with the emotional significance of stimuli, and executive regions concerned with planning and consequences. We hypothesized that adolescents with AN would show similar disturbed reward modulation within the striatum and the anterior cingulate cortex, a region connected to the striatum and involved in reward-guided action selection. Using functional magnetic resonance imaging, twenty-two adolescent females (10 restricting-type AN, 12 healthy volunteers) performed a monetary guessing task. Time series data associated with monetary wins and losses within striatal and cingulate regions of interest were subjected to a linear mixed effects analysis. All participants responded more strongly to wins versus losses in limbic and anterior executive striatal territories. However, AN participants exhibited an exaggerated response to losses compared to wins in posterior executive and sensorimotor striatal regions, suggesting altered function in circuitry responsible for coding the affective context of stimuli and action selection based upon these valuations. As AN individuals are particularly sensitive to criticism, failure, and making mistakes, these findings may reflect the neural processes responsible for a bias in those with AN to exaggerate negative consequences.
从神经性厌食症（AN）中康复的成年人在与刺激的情感意义相关的纹状体边缘区域以及与计划和后果相关的执行区域中表现出改变的奖励调节。我们假设患有 AN 的青少年在纹状体和前扣带皮层（与纹状体相连并参与奖励引导的动作选择的区域）中会表现出类似的受干扰的奖励调节。使用功能磁共振成像，对 22 名青春期女性（10 名限制型 AN，12 名健康志愿者）进行了货币猜测任务。与纹状体和扣带感兴趣区域内的货币收益和损失相关的时间序列数据被进行线性混合效应分析。所有参与者在边缘和前执行纹状体区域对收益的反应比对损失的反应更强。然而，与收益相比，AN 参与者在后部执行和感觉运动纹状体区域对损失的反应更为强烈，这表明负责编码刺激情感背景和基于这些评估进行动作选择的电路功能发生了改变。由于 AN 个体对批评、失败和犯错特别敏感，这些发现可能反映了那些对负面后果夸大的人的神经过程的偏见。
