A comparison of alclofenac and indomethacin in the relief of rheumatoid morning stiffness.

In a double-blind within-patient comparison of indomethacin, alclofenac and placebo taken as a single daily dose at bedtime by 29 rheumatoid out-patients, both drugs proved superior to placebo. Seventeen patients expressed a preference for indomethacin and 10 found alclofenac equal or superior in effect. The lower incidence of gastric irritation with alclofenac is confirmed and suggests its use in subjects intolerant of indomethacin.