阿氯芬酸与吲哚美辛缓解类风湿性晨僵的比较。

A comparison of alclofenac and indomethacin in the relief of rheumatoid morning stiffness.

作者信息

White A G, Martin V M

出版信息

Curr Med Res Opin. 1975;3(5):329-32. doi: 10.1185/03007997509114783.

Abstract

In a double-blind within-patient comparison of indomethacin, alclofenac and placebo taken as a single daily dose at bedtime by 29 rheumatoid out-patients, both drugs proved superior to placebo. Seventeen patients expressed a preference for indomethacin and 10 found alclofenac equal or superior in effect. The lower incidence of gastric irritation with alclofenac is confirmed and suggests its use in subjects intolerant of indomethacin.

摘要

在一项双盲的患者自身对照研究中，29名类风湿性关节炎门诊患者在睡前每日服用一次消炎痛、阿氯芬酸和安慰剂，结果显示两种药物均优于安慰剂。17名患者表示更喜欢消炎痛，10名患者认为阿氯芬酸的效果相同或更好。阿氯芬酸胃肠道刺激发生率较低得到了证实，这表明它可用于不能耐受消炎痛的患者。