STZ 诱导糖尿病大鼠肾功能的影响：对选定代谢标志物的影响。
The Effects of Methanolic Extract on Kidney Function in STZ-Induced Diabetic Rats: Effects on Selected Metabolic Markers.
机构信息
School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.
出版信息
J Diabetes Res. 2018 Jun 13;2018:7341242. doi: 10.1155/2018/7341242. eCollection 2018.
BACKGROUND
Studies suggest that () possesses hypoglycaemic effects. The effects of on diabetic complications such as DN, however, have not been established. Accordingly, this study seeks to investigate the effects of on kidney function in STZ-induced diabetic rats.
METHODS
Methanolic extracts (ME) of 's leaves were used in this study. Short-term effects of methanolic extract on kidney function and MAP were studied in STZ-induced diabetic rats treated twice daily with methanolic extract (250 mg/kg), insulin (175 g/kg, s.c.), and metformin (500 mg/kg) for 5 weeks.
RESULTS
methanolic extract significantly increased Na excretion outputs in STZ-induced diabetic rats by comparison to STZ-diabetic control rats. methanolic extract significantly increased GFR in STZ-diabetic rats with a concomitant decrease in creatinine concentration and also reduced kidney-to-body ratio, albumin excretion rate (AER), and albumin creatinine ratio (ACR). methanolic extract significantly reduced MAP in STZ-diabetic animals by comparison with STZ-diabetic control animals. These results suggest that methanolic extract not only lowers blood glucose but also has beneficial effects on kidney function and blood pressure.
CONCLUSION
These findings suggest that may have beneficial effects on some processes that are associated with renal derangement in STZ-induced diabetic rats.
背景
研究表明（）具有降血糖作用。然而，关于对糖尿病并发症（如 DN）的影响尚未确定。因此，本研究旨在探讨在链脲佐菌素诱导的糖尿病大鼠中，对肾脏功能的影响。
方法
本研究采用的是叶片的甲醇提取物（ME）。在 STZ 诱导的糖尿病大鼠中，每天两次给予 甲醇提取物（250mg/kg）、胰岛素（175μg/kg，皮下注射）和二甲双胍（500mg/kg），持续 5 周，研究其对短期肾脏功能和平均动脉压（MAP）的影响。
结果
与 STZ 糖尿病对照大鼠相比，甲醇提取物显著增加了 STZ 诱导的糖尿病大鼠的钠排泄量。与 STZ 糖尿病对照大鼠相比，甲醇提取物显著增加了 STZ 糖尿病大鼠的肾小球滤过率（GFR），同时降低了肌酐浓度，还降低了肾脏/体重比、白蛋白排泄率（AER）和白蛋白肌酐比（ACR）。与 STZ 糖尿病对照大鼠相比，甲醇提取物显著降低了 STZ 糖尿病动物的平均动脉压（MAP）。这些结果表明，不仅降低了血糖，而且对肾脏功能和血压有有益的影响。
结论
这些发现表明，可能对 STZ 诱导的糖尿病大鼠中与肾脏紊乱相关的某些过程具有有益的影响。
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