Planegger Andrea, Uyulmaz Semra, Poskevicius Audrius, Zbinden Andrea, Müller Nicolas J, Calcagni Maurizio
Department of Plastic Surgery and Hand Surgery, University Hospital Zurich, Zurich, Switzerland.
Department of General, Emergency and Visceral Surgery, Cantonal Hospital Obwalden, Sarnen, Switzerland.
Plast Reconstr Surg Glob Open. 2022 Apr 8;10(4):e4230. doi: 10.1097/GOX.0000000000004230. eCollection 2022 Apr.
Invasive fungal infections from , a fungus belonging to the have been rarely reported in central European climate zones. This study aims to raise awareness of invasive cutaneous infections with species. The first case of a cutaneous infection was diagnosed in Switzerland in an immunocompetent 79-year-old patient. A minor skin trauma of her left lower leg led to a fulminant infection causing necrosis and extensive loss of tissue. The combination of surgical debridement and administration of antifungal agents averted a prolonged course with a possible worse outcome. A pedicled hemisoleus muscle flap was used to reconstruct the defect and treatment was continued for 63 days.
A systematic review in accordance with the Preferred Reporting Items for Systematic review and Meta-Analysis guidelines was conducted to identify all European cases of infection with species in immunocompetent hosts. The epidemiology, clinical presentation, microbiological diagnosis, and management of cases reported in Europe were summarized and analyzed.
The prognosis of soft tissue infections with species. depends on early diagnosis and appropriate antifungal and surgical treatment. Reconstruction can be successful under ongoing antifungal treatment.
属于[具体真菌属]的[真菌名称]引起的侵袭性真菌感染在中欧气候区鲜有报道。本研究旨在提高对[真菌名称]物种引起的侵袭性皮肤感染的认识。瑞士一名79岁免疫功能正常的患者被诊断为首例皮肤感染。她左小腿的轻微皮肤创伤导致暴发性感染，引起坏死和广泛的组织损失。手术清创和抗真菌药物的联合应用避免了病程延长和可能更差的结局。采用带蒂半膜肌肌瓣修复缺损，并持续治疗63天。
按照系统评价和Meta分析的首选报告项目指南进行系统评价，以确定欧洲免疫功能正常宿主中所有[真菌名称]物种感染的病例。总结并分析了欧洲报告病例的流行病学、临床表现、微生物学诊断和管理。
[真菌名称]物种引起的软组织感染的预后取决于早期诊断以及适当的抗真菌和手术治疗。在持续抗真菌治疗下重建可以成功。
