Cutaneous Invasive Fungal Infections with Species in Immunocompetent Patients in Europe: A Systematic Review and Case Report.

UNLABELLED

Invasive fungal infections from , a fungus belonging to the have been rarely reported in central European climate zones. This study aims to raise awareness of invasive cutaneous infections with species. The first case of a cutaneous infection was diagnosed in Switzerland in an immunocompetent 79-year-old patient. A minor skin trauma of her left lower leg led to a fulminant infection causing necrosis and extensive loss of tissue. The combination of surgical debridement and administration of antifungal agents averted a prolonged course with a possible worse outcome. A pedicled hemisoleus muscle flap was used to reconstruct the defect and treatment was continued for 63 days.

METHODS

A systematic review in accordance with the Preferred Reporting Items for Systematic review and Meta-Analysis guidelines was conducted to identify all European cases of infection with species in immunocompetent hosts. The epidemiology, clinical presentation, microbiological diagnosis, and management of cases reported in Europe were summarized and analyzed.

CONCLUSIONS

The prognosis of soft tissue infections with species. depends on early diagnosis and appropriate antifungal and surgical treatment. Reconstruction can be successful under ongoing antifungal treatment.