Shi Yi, Gong Hongli, Zhou Liang, Tao Lei, Shi Yong, Cao Wenjun, Cheng Lei
Department of Clinical Laboratory, Fudan University, Shanghai, China.
ORL J Otorhinolaryngol Relat Spec. 2011;73(6):295-300. doi: 10.1159/000330955. Epub 2011 Sep 22.
To investigate the presence of Helicobacter pylori in the larynx, and to identify the relationship between H. pylori infection and laryngeal squamous cell carcinoma in a male population.
This study included 59 male patients with laryngeal squamous cell carcinoma and 41 control subjects. Nested polymerase chain reaction and target fragment sequencing were used to detect the presence of H. pylori in laryngeal mucosa. Logistic regression analysis was used to assess the association between H. pylori infection and laryngeal cancer.
H. pylori was present in a significantly greater number of patients with laryngeal carcinoma (76.3%) than in control subjects (31.7%) (p < 0.001). The correlation between H. pylori infection and laryngeal cancer was highly significant (OR = 9.82, 95% CI [3.35, 28.80], p < 0.001).
The present study shows that H. pylori is present in the laryngeal mucosa of men, and supports a possible relationship between H. pylori infection and laryngeal squamous cell carcinoma in a male population.
研究喉中幽门螺杆菌的存在情况，并确定男性人群中幽门螺杆菌感染与喉鳞状细胞癌之间的关系。
本研究纳入了59例男性喉鳞状细胞癌患者和41例对照受试者。采用巢式聚合酶链反应和目标片段测序检测喉黏膜中幽门螺杆菌的存在情况。采用逻辑回归分析评估幽门螺杆菌感染与喉癌之间的关联。
喉癌患者中幽门螺杆菌的存在率（76.3%）显著高于对照受试者（31.7%）（p < 0.001）。幽门螺杆菌感染与喉癌之间的相关性非常显著（OR = 9.82，95% CI [3.35, 28.80]，p < 0.001）。
本研究表明男性喉黏膜中存在幽门螺杆菌，并支持男性人群中幽门螺杆菌感染与喉鳞状细胞癌之间可能存在的关系。
