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人类白血病T细胞系Molt-4克隆细胞对获得性免疫缺陷综合征逆转录病毒的易感性差异

Differential susceptibility to the acquired immunodeficiency syndrome retrovirus in cloned cells of human leukemic T-cell line Molt-4.

作者信息

Kikukawa R, Koyanagi Y, Harada S, Kobayashi N, Hatanaka M, Yamamoto N

出版信息

J Virol. 1986 Mar;57(3):1159-62. doi: 10.1128/JVI.57.3.1159-1162.1986.

DOI:10.1128/JVI.57.3.1159-1162.1986
PMID:2419583
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC252852/
Abstract

Cells of human leukemic T-cell line Molt-4 which were cloned in soft agarose from individual colonies were analyzed for the cytopathic effect and viral antigen expression after human T-cell lymphotropic virus type III infection. The induction of cytopathic effect and viral antigens by the infection varied significantly among the different cell clones. These clones did not show significant differences in the amount of OKT-4 antigen, a possible surface receptor for acquired immunodeficiency syndrome virus. Moreover, the virus-producing ability and the susceptibility to the virus of each clone appeared to be separable.

摘要

对从单个集落中在软琼脂糖中克隆的人白血病T细胞系Molt-4细胞，在感染人嗜T细胞病毒III型后分析其细胞病变效应和病毒抗原表达。感染诱导的细胞病变效应和病毒抗原在不同细胞克隆间差异显著。这些克隆在OKT-4抗原量上无显著差异，OKT-4抗原可能是获得性免疫缺陷综合征病毒的一种表面受体。此外，每个克隆的病毒产生能力和对病毒的敏感性似乎是可分离的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c65/252852/2faccf8545d2/jvirol00114-0457-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c65/252852/2faccf8545d2/jvirol00114-0457-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c65/252852/2faccf8545d2/jvirol00114-0457-a.jpg

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1
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Science. 1984 Jul 27;225(4660):381-5. doi: 10.1126/science.6330891.
2
Antibodies to the core protein of lymphadenopathy-associated virus (LAV) in patients with AIDS.艾滋病患者体内针对淋巴结病相关病毒（LAV）核心蛋白的抗体。
Science. 1984 Jul 20;225(4659):321-3. doi: 10.1126/science.6330889.
3
Selective tropism of lymphadenopathy associated virus (LAV) for helper-inducer T lymphocytes.
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Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):7093-7098. doi: 10.1073/pnas.1801849115. Epub 2018 Jun 11.
4
HIV-1 Nef inhibits Protease activity and its absence alters protein content of mature viral particles.HIV-1 Nef抑制蛋白酶活性，其缺失会改变成熟病毒颗粒的蛋白质含量。
PLoS One. 2014 Apr 18;9(4):e95352. doi: 10.1371/journal.pone.0095352. eCollection 2014.
5
The D-amino acid peptide D3 reduces amyloid fibril boosted HIV-1 infectivity.D-氨基酸肽 D3 降低了淀粉样纤维增强的 HIV-1 感染力。
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Antimicrob Agents Chemother. 2013 Mar;57(3):1323-31. doi: 10.1128/AAC.01711-12. Epub 2012 Dec 28.
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4
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5
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7
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8
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9
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