Nery Max Weyler, Martelli Celina Maria Turchi, Silveira Erika Aparecida, de Sousa Clarissa Alencar, Falco Marianne de Oliveira, de Castro Aline de Cássia Oliveira, Esper Jorge Tannus, Souza Luis Carlos Silva e, Turchi Marília Dalva
Postgraduate Studies Program, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Brazil ; Department of Medicine, Catholic University of Goiás, Brazil.
ScientificWorldJournal. 2013 Oct 21;2013:969281. doi: 10.1155/2013/969281. eCollection 2013.
This study aims to estimate the risk of cardiovascular disease (CVD) and to assess the agreement between the Framingham, Framingham with aggravating factors, PROCAM, and DAD equations in HIV-infected patients. A cross-sectional study was conducted in an outpatient centre in Brazil. 294 patients older than 19 years were enrolled. Estimates of 10-year cardiovascular risk were calculated. The agreement between the CVD risk equations was assessed using Cohen's kappa coefficient. The participants' mean age was 36.8 years (SD = 10.3), 76.9% were men, and 66.3% were on antiretroviral therapy. 47.8% of the participants had abdominal obesity, 23.1% were current smokers, 20.0% had hypertension, and 2.0% had diabetes. At least one lipid abnormality was detected in 72.8%, and a low HDL-C level was the most common. The majority were classified as having low risk for CV events. The percentage of patients at high risk ranged from 0.4 to 5.7. The PROCAM score placed the lowest proportion of the patients into a high-risk group, and the Framingham equation with aggravating factors placed the highest proportion of patients into the high-risk group. Data concerning the comparability of different tools are informative for estimating the risk of CVD, but accuracy of the outcome predictions should also be considered.
本研究旨在评估心血管疾病（CVD）风险，并评估弗雷明汉、含加重因素的弗雷明汉、PROCAM和DAD方程在HIV感染患者中的一致性。在巴西的一个门诊中心进行了一项横断面研究。纳入了294名年龄超过19岁的患者。计算了10年心血管风险估计值。使用科恩kappa系数评估CVD风险方程之间的一致性。参与者的平均年龄为36.8岁（标准差=10.3），76.9%为男性，66.3%正在接受抗逆转录病毒治疗。47.8%的参与者有腹部肥胖，23.1%为当前吸烟者，20.0%患有高血压，2.0%患有糖尿病。72.8%的人检测到至少一种血脂异常，高密度脂蛋白胆固醇（HDL-C）水平低最为常见。大多数人被归类为心血管事件低风险。高风险患者的百分比在0.4%至5.7%之间。PROCAM评分将最低比例的患者归入高风险组，含加重因素的弗雷明汉方程将最高比例的患者归入高风险组。有关不同工具可比性的数据对于评估CVD风险具有参考价值，但也应考虑结果预测的准确性。
