Huibers Minke H W, Visser Douwe H, Deckers Martine M L, van Schoor Natasja M, van Furth A Marceline, Wolf Bart H M
Department of Paediatrics, Sint Lucas Andreas Hospital (SLAZ), Amsterdam, The Netherlands.
Eur J Pediatr. 2014 May;173(5):583-8. doi: 10.1007/s00431-013-2198-x. Epub 2013 Nov 21.
The aim of this study was to determine the prevalence of 25-hydroxyvitamin D (25(OH)D) deficiency in a hospital-based population of both native Dutch and non-Western immigrants and to investigate the influence of immigrant status on the prevalence of vitamin D deficiency. A cross-sectional survey was conducted among 132 patients (1-18 years of age) visiting the paediatric outpatient department. Serum levels of 25(OH)D were measured using high-performance liquid chromatography. Cut-off levels of 30 and 50 nmol/l for serum 25(OH)D were evaluated. One third of the patients had serum 25(OH)D levels below 30 nmol/l, and half of the study population had serum levels below 50 nmol/l. Non-Western immigrants had an increased risk for vitamin D deficiency compared to their native Dutch peers [25(OH)D of <30 nmol/l, p = 0.03, odds ratio (OR) 3.87 (95 % confidence interval (CI) 1.13-13.29); 25(OH)D of <50 nmol/l, p = 0.02, OR 3.57 (95 % CI 1.26-10.14)] with the highest risk for first-generation non-Western immigrants.
Vitamin D deficiency in the paediatric population is still a matter of concern in the Netherlands, in particular among first-generation non-Western immigrants. We therefore strongly recommend vitamin D supplementation for all non-Western immigrants, regardless of age, skin type or season. Health-care staff who work with non-Western immigrants should be aware of the prevalence and implications of vitamin D deficiency.
本研究的目的是确定荷兰本土儿童和非西方移民在医院就诊人群中25-羟基维生素D（25(OH)D）缺乏的患病率，并调查移民身份对维生素D缺乏患病率的影响。对132名（1至18岁）到儿科门诊就诊的患者进行了横断面调查。采用高效液相色谱法测定血清25(OH)D水平。评估了血清25(OH)D的截断水平为30和50 nmol/l。三分之一的患者血清25(OH)D水平低于30 nmol/l，一半的研究人群血清水平低于50 nmol/l。与荷兰本土同龄人相比，非西方移民维生素D缺乏的风险增加[25(OH)D<30 nmol/l，p = 0.03，优势比（OR）3.87（95%置信区间（CI）1.13 - 13.29）；25(OH)D<50 nmol/l，p = 0.02，OR 3.57（95%CI 1.26 - 10.14）]，第一代非西方移民风险最高。
在荷兰，儿科人群中的维生素D缺乏仍然是一个令人担忧的问题，特别是在第一代非西方移民中。因此，我们强烈建议所有非西方移民，无论年龄、皮肤类型或季节，都补充维生素D。与非西方移民打交道的医护人员应了解维生素D缺乏的患病率及其影响。
