CEACAM1 的缺失将肥胖和非酒精性脂肪性肝炎（NASH）中的炎症与胰岛素抵抗联系起来。
CEACAM1 loss links inflammation to insulin resistance in obesity and non-alcoholic steatohepatitis (NASH).
机构信息
Center for Diabetes and Endocrine Research, University of Toledo, Health Science Campus, 3000 Arlington Avenue, Mail stop 1009, Toledo, OH, 43614, USA,
出版信息
Semin Immunopathol. 2014 Jan;36(1):55-71. doi: 10.1007/s00281-013-0407-3. Epub 2013 Nov 21.
Abstract
Mounting epidemiological evidence points to an association between metabolic syndrome and non-alcoholic steatohepatitis (NASH), an increasingly recognized new epidemic. NASH pathologies include hepatocellular ballooning, lobular inflammation, hepatocellular injury, apoptosis, and hepatic fibrosis. We will review the relationship between insulin resistance and inflammation in visceral obesity and NASH in an attempt to shed more light on the pathogenesis of these major metabolic diseases. Moreover, we will identify loss of the carcinoembryonic antigen-related cell adhesion molecule 1 as a unifying mechanism linking the immunological and metabolic abnormalities in NASH.
摘要
越来越多的研究证据表明，代谢综合征与非酒精性脂肪性肝炎（NASH）之间存在关联，后者是一种日益被认识的新流行疾病。NASH 的病理包括肝细胞气球样变、肝小叶炎症、肝细胞损伤、细胞凋亡和肝纤维化。我们将回顾内脏肥胖和 NASH 中胰岛素抵抗与炎症之间的关系，试图进一步阐明这些主要代谢疾病的发病机制。此外，我们将确定癌胚抗原相关细胞黏附分子 1 的缺失作为将 NASH 中的免疫和代谢异常联系起来的统一机制。
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