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慢性胰腺炎的理解和治疗。

Understanding and treatment of chronic pancreatitis.

机构信息

Asbjørn Mohr Drewes, Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, 9100 Aalborg, Denmark.

出版信息

World J Gastroenterol. 2013 Nov 14;19(42):7219-21. doi: 10.3748/wjg.v19.i42.7219.

DOI:10.3748/wjg.v19.i42.7219
PMID:24259951
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3831202/
Abstract

Chronic pancreatitis is characterized by an inflammatory process of the pancreas, which is replaced by fibrosis and progressive destruction. The three major clinical features of chronic pancreatitis are pain, maldigestion, and diabetes. Chronic pancreatitis has a profound impact on social life and employment patterns. In the current issue, different topics highlight experimental models of chronic pancreatitis and bridge findings from recent research to bedside. Although the disease is still difficult to treat the current papers represent useful guidelines on how to approach chronic pancreatitis in the clinical settings with the major aim to improve the patient's suffering and quality of life.

摘要

慢性胰腺炎的特征为胰腺炎症过程,被纤维化为渐进性破坏所取代。慢性胰腺炎的三大临床特征为疼痛、消化不良和糖尿病。慢性胰腺炎对社会生活和就业模式有深远影响。在本期中,不同专题突出了慢性胰腺炎的实验模型,并将最近的研究结果与临床联系起来。尽管该疾病仍然难以治疗,但目前的论文提供了有关如何在临床环境中处理慢性胰腺炎的有用指南,主要目的是改善患者的痛苦和生活质量。

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Understanding and treatment of chronic pancreatitis.慢性胰腺炎的理解和治疗。
World J Gastroenterol. 2013 Nov 14;19(42):7219-21. doi: 10.3748/wjg.v19.i42.7219.
2
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Clinical profile and outcome of chronic pancreatitis in children.儿童慢性胰腺炎的临床特征和结局。
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water extract alleviates chronic pancreatitis by deactivating pancreatic stellate cells.水提取物通过使胰腺星状细胞失活来缓解慢性胰腺炎。
Front Pharmacol. 2022 Aug 29;13:941955. doi: 10.3389/fphar.2022.941955. eCollection 2022.
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Gut microbiome as a response marker for pancreatic enzyme replacement therapy in a porcine model of exocrine pancreas insufficiency.肠道微生物组作为外分泌胰腺功能不全猪模型中胰腺酶替代治疗的反应标志物。
Microb Cell Fact. 2020 Dec 3;19(1):221. doi: 10.1186/s12934-020-01482-2.
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HDAC inhibitors promote pancreatic stellate cell apoptosis and relieve pancreatic fibrosis by upregulating miR-15/16 in chronic pancreatitis.组蛋白去乙酰化酶抑制剂通过上调慢性胰腺炎中的 miR-15/16 促进胰腺星状细胞凋亡并缓解胰腺纤维化。
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本文引用的文献

1
Endoscopic management of complications of chronic pancreatitis.慢性胰腺炎并发症的内镜治疗。
World J Gastroenterol. 2013 Nov 14;19(42):7308-15. doi: 10.3748/wjg.v19.i42.7308.
2
Pharmacological challenges in chronic pancreatitis.慢性胰腺炎的药物治疗挑战。
World J Gastroenterol. 2013 Nov 14;19(42):7302-7. doi: 10.3748/wjg.v19.i42.7302.
3
Pharmacological pain management in chronic pancreatitis.慢性胰腺炎的药物止痛治疗。
World J Gastroenterol. 2013 Nov 14;19(42):7292-301. doi: 10.3748/wjg.v19.i42.7292.
4
Pain and chronic pancreatitis: a complex interplay of multiple mechanisms.疼痛与慢性胰腺炎:多种机制的复杂相互作用。
World J Gastroenterol. 2013 Nov 14;19(42):7282-91. doi: 10.3748/wjg.v19.i42.7282.
5
Diagnosis and treatment of diabetes mellitus in chronic pancreatitis.慢性胰腺炎糖尿病的诊断与治疗。
World J Gastroenterol. 2013 Nov 14;19(42):7276-81. doi: 10.3748/wjg.v19.i42.7276.
6
Nutrition in chronic pancreatitis.慢性胰腺炎的营养。
World J Gastroenterol. 2013 Nov 14;19(42):7267-75. doi: 10.3748/wjg.v19.i42.7267.
7
Diagnosis and treatment of pancreatic exocrine insufficiency.胰腺外分泌功能不全的诊断与治疗。
World J Gastroenterol. 2013 Nov 14;19(42):7258-66. doi: 10.3748/wjg.v19.i42.7258.
8
Ultrasonography in diagnosing chronic pancreatitis: new aspects.超声诊断慢性胰腺炎:新观点。
World J Gastroenterol. 2013 Nov 14;19(42):7247-57. doi: 10.3748/wjg.v19.i42.7247.
9
Morphological and functional evaluation of chronic pancreatitis with magnetic resonance imaging.磁共振成像对慢性胰腺炎的形态学和功能评估。
World J Gastroenterol. 2013 Nov 14;19(42):7241-6. doi: 10.3748/wjg.v19.i42.7241.
10
Pathophysiology of chronic pancreatitis.慢性胰腺炎的病理生理学。
World J Gastroenterol. 2013 Nov 14;19(42):7231-40. doi: 10.3748/wjg.v19.i42.7231.