Behavioural Entomology Group, Jodrell Laboratory, Royal Botanic Gardens Kew, Richmond, Surrey, UK.
J Chem Ecol. 1990 Nov;16(11):3167-96. doi: 10.1007/BF00979618.
Eleven polyhydroxy alkaloids of plant origin were tested for anti-feedant effects against larvae of the lepidopteransSpodoptera littoralis, Spodoptera frugiperda, Heliothis virescens, andHelicoverpa armigera. Data from behavioral and electrophysiological investigations were correlated to reveal information on the mode of action of the antifeedants. The pyrrolidine DMDP was an effective antifeedant for all four species, whereas the piperidines fagomine and XZ-1 and the pyrrolizidine alexine were all ineffective as antifeedants. The activity of the pyrrolidines CYB-3 and DAB-1, the piperidines DNJ, DMJ, and BR1, and the bicyclic octahydroindolizine castanospermine varied among species. The investigation focuses on the structural similarities between some of the alkaloids and some common phagostimulatory sugars and illustrates a neural interaction involving the neurons that are differentially responsive to alkaloids and sugars. InS. littoralis, the neurons responding specifically to the alkaloids DMDP, DAB-1, and castanospermine and to the sugars fructose, sucrose, and glucose are more active when the compounds are applied singly than when an alkaloid and a sugar are applied together. The implications for the occurrence and functioning of different sugar receptor sites are discussed.
11 种植物来源的多羟基生物碱被测试了对鳞翅目昆虫 Spodoptera littoralis、Spodoptera frugiperda、Heliothis virescens 和 Helicoverpa armigera 幼虫的拒食作用。将行为和电生理研究的数据进行相关分析，以揭示拒食剂作用模式的信息。吡咯烷 DMDP 对所有四种物种都是有效的拒食剂，而哌啶 fagomine 和 XZ-1 以及吡咯里西啶 alexine 都没有拒食作用。吡咯烷 CYB-3 和 DAB-1、哌啶 DNJ、DMJ 和 BR1 以及双环八氢吲哚里西啶 castanospermine 的活性在物种间有所不同。该研究集中于一些生物碱和一些常见的取食刺激糖之间的结构相似性，并说明了涉及对生物碱和糖有不同反应的神经元的神经相互作用。在 S. littoralis 中，对生物碱 DMDP、DAB-1 和 castanospermine 以及糖果糖、蔗糖和葡萄糖有特异性反应的神经元在单独施用这些化合物时比同时施用一种生物碱和一种糖时更活跃。讨论了不同糖受体位点的出现和功能的意义。
