Emerg Infect Dis. 2013 Dec;19(12):2021-4. doi: 10.3201/eid1912.130340.
We characterized 7 highly pathogenic avian influenza A(H5N1) viruses isolated from poultry in China during 2009-2012 and found that they belong to clade 2.3.4 but do not fit within the 3 defined subclades. Antigenic drift in subtype H5N1 variants may reduce the efficacy of vaccines designed to control these viruses in poultry.
我们对 2009-2012 年期间在中国家禽中分离到的 7 株高致病性禽流感 H5N1 病毒进行了特征分析,发现它们属于 2.3.4 分支,但不属于已定义的 3 个亚分支。亚型 H5N1 变异株的抗原漂移可能降低针对这些病毒的疫苗的防控效果。