Srivastava Nishit, James Jackson, Narayan K S
Molecular Electronics Laboratory; Chemistry and Physics of Materials Unit; Jawaharlal Nehru Centre for Advanced Scientific Research; Bangalore, India.
Neural Stem Cell Biology Laboratory; Neurobiology Division; Rajiv Gandhi Centre for Biotechnology; Trivandrum, India.
Organogenesis. 2014 Jan 1;10(1):1-5. doi: 10.4161/org.27213. Epub 2013 Nov 26.
This commentary discusses and summarizes the key highlights of our recently reported work entitled "Neuronal Differentiation of Embryonic Stem Cell Derived Neuronal Progenitors Can Be Regulated by Stretchable Conducting Polymers." The prospect of controlling the mechanical-rigidity and the surface conductance properties offers a unique combination for tailoring the growth and differentiation of neuronal cells. We emphasize the utility of transparent elastomeric substrates with coatings of electrically conducting polymer to realize the desired substrate-characteristics for cellular development processes. Our study showed that neuronal differentiation from ES cells is highly influenced by the specific substrates on which they are growing. Thus, our results provide a better strategy for regulated neuronal differentiation by using such functional conducting surfaces.
本评论讨论并总结了我们最近发表的题为《可拉伸导电聚合物可调节胚胎干细胞衍生神经元祖细胞的神经元分化》的工作的关键要点。控制机械刚性和表面电导特性的前景为定制神经元细胞的生长和分化提供了独特的组合。我们强调了具有导电聚合物涂层的透明弹性体基质在实现细胞发育过程所需基质特性方面的实用性。我们的研究表明，胚胎干细胞的神经元分化受到其生长的特定基质的高度影响。因此，我们的结果为利用这种功能性导电表面进行神经元分化调控提供了更好的策略。
