机械生物学入门指南。
A hitchhiker's guide to mechanobiology.
机构信息
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
出版信息
Dev Cell. 2011 Jul 19;21(1):35-47. doi: 10.1016/j.devcel.2011.06.015.
Abstract
More than a century ago, it was proposed that mechanical forces could drive tissue formation. However, only recently with the advent of enabling biophysical and molecular technologies are we beginning to understand how individual cells transduce mechanical force into biochemical signals. In turn, this knowledge of mechanotransduction at the cellular level is beginning to clarify the role of mechanics in patterning processes during embryonic development. In this perspective, we will discuss current mechanotransduction paradigms, along with the technologies that have shaped the field of mechanobiology.
摘要
一个多世纪以前，就有人提出机械力可以驱动组织形成。然而，直到最近，随着能够实现的生物物理和分子技术的出现，我们才开始了解单个细胞如何将机械力转化为生化信号。反过来，这种细胞水平的力转导知识正在开始阐明力学在胚胎发育过程中的模式形成过程中的作用。在这个观点中，我们将讨论当前的力转导范例，以及塑造力生物学领域的技术。
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