Ghorbanihaghjo Amir, Safa Javid, Alizadeh Samira, Argani Hassan, Rashtchizadeh Nadereh, Taghinia Mohammad Vahid, Abbasi Mehran Mesgari
Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
J Health Popul Nutr. 2013 Sep;31(3):343-9. doi: 10.3329/jhpn.v31i3.16826.
The study examined the influence of fish oil (FO) supplementation on serum 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels as indicated by DNA damage markers and total antioxidant capacity (TAC) among male cigarette smokers. This double-blind, placebo-controlled randomized study was conducted among healthy cigarette smokers (n=40) who were part of a larger prospective cohort study. Twenty smokers were randomly selected to receive FO for 3 months (1 g/day), and another 20 smokers received a placebo for 3 months; 8-OHdG and TAC levels were measured in blood samples before and after the intervention. Serum 8-OHdG significantly decreased (p=0.001) and TAC increased (p<0.001) after 3 months of treatment with FO. Between baseline and endline, the difference in 8-OHdG significantly correlated with the difference in TAC among smokers who received FO (r=-0.540, p=0.014). The study provides evidence that FO supplementation can modify decreased antioxidants and increased oxidative DNA damage in cigarette smokers.
该研究考察了补充鱼油（FO）对男性吸烟者血清8-羟基-2'-脱氧鸟苷（8-OHdG）水平（由DNA损伤标志物指示）和总抗氧化能力（TAC）的影响。这项双盲、安慰剂对照的随机研究在健康吸烟者（n = 40）中进行，这些吸烟者是一项更大的前瞻性队列研究的一部分。随机选择20名吸烟者接受3个月的FO（1克/天），另外20名吸烟者接受3个月的安慰剂；在干预前后测量血样中的8-OHdG和TAC水平。用FO治疗3个月后，血清8-OHdG显著降低（p = 0.001），TAC升高（p < 0.001）。在基线和终点之间，接受FO的吸烟者中8-OHdG的差异与TAC的差异显著相关（r = -0.540，p = 0.014）。该研究提供了证据，表明补充FO可以改善吸烟者抗氧化剂减少和氧化性DNA损伤增加的状况。
