Zhao Xin, Xu Dan, Li Yi, Zhang Jiangyan, Liu Tingting, Ji Yinli, Wang Jufang, Zhou Guangming, Xie Xiaodong
Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China.
J Bone Miner Metab. 2014 May;32(3):221-31. doi: 10.1007/s00774-013-0537-7. Epub 2013 Dec 6.
Osteoporosis is caused by an unbalance between bone formation and bone resorption. Bone homeostasis is regulated by intricate mechanisms. Recently, a novel class of regulatory factors termed microRNAs (miRNAs) has been found to play a crucial role in cell cycle control, apoptosis and other cellular processes including metabolism and differentiation. Published data have shown that some miRNAs regulate bone homeostasis, including bone formation, resorption, remodeling, repair and bone-related disease, by regulating the expression of certain cytokines and transcription factors. This review highlights the current knowledge of miRNAs and their involvement in the regulation of bone formation, bone resorption and the pathways regulating the progression of osteoporosis.
骨质疏松症是由骨形成与骨吸收之间的失衡引起的。骨稳态由复杂的机制调节。最近，一类称为微小RNA（miRNA）的新型调节因子已被发现，在细胞周期控制、细胞凋亡以及包括代谢和分化在内的其他细胞过程中发挥关键作用。已发表的数据表明，一些miRNA通过调节某些细胞因子和转录因子的表达来调节骨稳态，包括骨形成、吸收、重塑、修复以及与骨相关的疾病。本综述重点介绍了目前关于miRNA的知识及其在骨形成、骨吸收调节以及骨质疏松症进展调控途径中的作用。
