Choi Yong Jun, Shin Jung A, Kim Yong Hoon, Cha Soon Joo, Cho Joong-Yang, Kang Seung Hee, Yi Seong Yoon, Lee Hye Ran
Department of Internal Medicine, Inje University Ilsan Paik Hospital, 170 Juhwa-ro, Ilsanseo-gu, Goyang-si, Gyeonggi-do 411-706, Republic of Korea.
Case Rep Oncol Med. 2013;2013:492329. doi: 10.1155/2013/492329. Epub 2013 Nov 12.
Neurolymphomatosis (NL) is a rare clinical disease where neoplastic cells invade the cranial nerves and peripheral nerve roots, plexus, or other nerves in patients with hematologic malignancy. Most NL cases are caused by B-cell non-Hodgkin's lymphoma (NHL). Diagnosis can be made by imaging with positron emission tomography (PET) and magnetic resonance imaging (MRI). We experienced two cases of NL involving the brachial plexus in patients with NHL. One patient, who had NHL with central nervous system (CNS) involvement, experienced complete remission after 8 cycles of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy but relapsed into NL of the brachial plexus 5 months later. The other patient, who suffered from primary central nervous system lymphoma (PCNSL), had been undergoing chemoradiotherapy but progressed to NL of the brachial plexus.
神经淋巴瘤（NL）是一种罕见的临床疾病，在血液系统恶性肿瘤患者中，肿瘤细胞侵犯颅神经和周围神经根、神经丛或其他神经。大多数NL病例由B细胞非霍奇金淋巴瘤（NHL）引起。诊断可通过正电子发射断层扫描（PET）和磁共振成像（MRI）进行影像学检查。我们遇到了两例NHL患者发生臂丛神经受累的NL病例。一名患有累及中枢神经系统（CNS）的NHL患者，在接受8个周期的R-CHOP（利妥昔单抗、环磷酰胺、多柔比星、长春新碱和泼尼松）化疗后完全缓解，但5个月后复发为臂丛神经NL。另一名患有原发性中枢神经系统淋巴瘤（PCNSL）的患者，一直在接受放化疗，但病情进展为臂丛神经NL。
