曼戈罗霉素 A 和 B：从 Lechevalieria aerocolonigenes K10-0216 中分离得到的两种新型环十五烷化合物的结构和抗锥虫活性。
Mangromicins A and B: structure and antitrypanosomal activity of two new cyclopentadecane compounds from Lechevalieria aerocolonigenes K10-0216.
机构信息
Research Organization for Infection Control Sciences, Kitasato University, Tokyo, Japan.
1] Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan [2] Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 2014 Mar;67(3):253-60. doi: 10.1038/ja.2013.129. Epub 2013 Dec 11.
Two new cyclopentadecane antibiotics, named mangromicins A and B, were separated out from the culture broth of Lechevalieria aerocolonigenes K10-0216 by Diaion HP-20, silica gel and ODS column chromatography, and were finally purified by HPLC. The chemical structures of the two novel compounds were elucidated by instrumental analyses, including various NMR, MS and X-ray crystallography. Mangromicins A and B consist of cyclopentadecane skeletons with a tetrahydrofuran unit and a 5,6-dihydro-4-hydroxy-2-pyrone moiety. Mangromicins A and B showed in vitro antitrypanosomal activity with IC50 values of 2.4 and 43.4 μg ml(-1), respectively. The IC50 values of both compounds were lower than those of cytotoxicity against MRC-5 human fetal lung fibroblast cells.
从 Lechevalieria aerocolonigenes K10-0216 的发酵液中分离出两种新型环十五烷抗生素，命名为 mangromicins A 和 B。通过 Diaion HP-20、硅胶和 ODS 柱层析，最后通过 HPLC 进行纯化。通过各种 NMR、MS 和 X 射线晶体学等仪器分析阐明了这两种新化合物的化学结构。Mangromicins A 和 B 由具有四氢呋喃单元和 5,6-二氢-4-羟基-2-吡喃酮部分的环十五烷骨架组成。Mangromicins A 和 B 表现出体外抗锥虫活性，IC50 值分别为 2.4 和 43.4μg/ml(-1)。这两种化合物的 IC50 值均低于对 MRC-5 人胎肺成纤维细胞的细胞毒性。
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