Kasper M, Goertchen R, Stosiek P, Perry G, Karsten U
Virchows Arch A Pathol Anat Histopathol. 1986;410(3):173-7. doi: 10.1007/BF00710822.
The expression of intermediate filament proteins in human brain ependyma and choroid plexus epithelium has been studied by immunohistochemistry using a panel of monoclonal antibodies directed against all five classes of intermediate filaments. Ependymal cells express GFAP and vimentin filaments, whereas plexus epithelium simultaneously contains neurofilaments, cytokeratins and vimentin, a phenomenon not previously observed in normal cells in vivo. By means of specific antibodies we were able to establish that cytokeratins 8 and 18 but not 19 are present in plexus epithelium.
利用一组针对所有五类中间丝的单克隆抗体,通过免疫组织化学方法研究了人脑海绵体室管膜和脉络丛上皮中中间丝蛋白的表达。室管膜细胞表达胶质纤维酸性蛋白(GFAP)和波形蛋白丝,而脉络丛上皮同时含有神经丝、细胞角蛋白和波形蛋白,这一现象在体内正常细胞中以前未被观察到。通过特异性抗体,我们能够确定脉络丛上皮中存在细胞角蛋白8和18,但不存在细胞角蛋白19。