Oldham Michael J, Coggins Christopher R E, McKinney Willie J
Regulatory Affairs, Altria Client Services Inc. , Richmond, VA , USA and.
Inhal Toxicol. 2013;25 Suppl 2:1-5. doi: 10.3109/08958378.2013.854429.
In addition to tobacco and cigarette ingredients, there are many non-tobacco components and processes used to manufacture commercial cigarettes. Proposed cigarette components and manufacturing process changes were evaluated using a tiered toxicological testing program.
The toxicological testing and evaluation of proposed changes to selected non-tobacco cigarette components and manufacturing processes are described in this special report.
Selected non-tobacco cigarette components and manufacturing processes were evaluated using experimental and control cigarettes. These experimental cigarettes were evaluated using mainstream smoke chemistry, bacterial mutagenicity and cytotoxicity assays. In some evaluations, 90-day nose-only mainstream smoke inhalation studies using rats were performed.
Some proposed design changes were not implemented, or limitations on their use were established. Most study results, however, were similar to those previously reported in the scientific literature for design changes in cigarette construction.
The studies reported in the series of publication demonstrate that our testing approach is feasible for evaluation of cigarette component and manufacturing process changes.
除了烟草和香烟成分外，商业香烟制造还使用许多非烟草成分和工艺。拟议的香烟成分和制造工艺变更通过分层毒理学测试程序进行评估。
本特别报告描述了对选定非烟草香烟成分和制造工艺拟议变更的毒理学测试与评估。
使用实验香烟和对照香烟对选定的非烟草香烟成分和制造工艺进行评估。这些实验香烟通过主流烟气化学、细菌致突变性和细胞毒性测定进行评估。在一些评估中，对大鼠进行了为期90天的仅经鼻吸入主流烟气研究。
一些拟议的设计变更未实施，或对其使用设定了限制。然而，大多数研究结果与科学文献中先前报道的香烟结构设计变更结果相似。
该系列出版物中报道的研究表明，我们的测试方法对于评估香烟成分和制造工艺变更是可行的。
