Werley Michael S, Jerome Ann M, DeSoi Darren J, Coggins Christopher R E, Oldham Michael J, McKinney Willie J
Regulatory Affairs, Altria Client Services Inc. , Richmond, Virginia , USA and.
Inhal Toxicol. 2013;25 Suppl 2:19-33. doi: 10.3109/08958378.2013.854431.
To comply with state requirements, cigarette manufacturers have added low-permeability bands to the cigarette paper. These bands can extinguish the cigarette when it is no longer being puffed by a smoker.
This study was conducted to evaluate the toxicology resulting from the addition of different types of bands to experimental cigarettes.
A battery of assays that are typically used in toxicology studies with cigarette smoke, namely smoke chemistry, in vitro mutagenicity and cytotoxicity, and inhalation studies with rats, were used to evaluate different band characteristics added to cigarette paper.
Although differences in the amount of band material was associated with an increase in some metals measured in mainstream tobacco smoke, it was not dose responsive to any band design parameter (base paper permeability, band width, band spacing, band chalk amount, or citrate). Occasional, minor differences were produced by the different types of bands; overall, there was no increased toxicity.
Although there were increases and decreases in some mainstream smoke constituents, the in vitro and in vivo testing performed demonstrated that low-permeability bands on cigarettes do not modify the toxicity of smoke inhaled by smokers.
为了符合国家要求，香烟制造商在卷烟纸上添加了低渗透性带。当吸烟者不再抽吸香烟时，这些带可以熄灭香烟。
本研究旨在评估在实验香烟中添加不同类型的带所产生的毒理学影响。
一系列通常用于香烟烟雾毒理学研究的试验，即烟雾化学、体外诱变性和细胞毒性以及大鼠吸入研究，被用于评估添加到卷烟纸上的不同带的特性。
尽管带材料的量的差异与主流烟草烟雾中某些金属含量的增加有关，但它对任何带设计参数（原纸渗透性、带宽、带间距、带白垩量或柠檬酸盐）均无剂量反应。不同类型的带偶尔会产生微小差异；总体而言，毒性没有增加。
尽管一些主流烟雾成分有增有减，但所进行的体外和体内测试表明，香烟上的低渗透性带不会改变吸烟者吸入烟雾的毒性。
