Coggins Christopher R E, Jerome Ann M, Lilly Patrick D, McKinney Willie J, Oldham Michael J
Carson Watts Consulting , King, NC , USA and.
Inhal Toxicol. 2013;25 Suppl 2:6-18. doi: 10.3109/08958378.2013.854430.
Adhesives are used in several different manufacturing operations in the production of cigarettes. The use of new, "high-speed-manufacture" adhesives (e.g. vinyl acetate based) could affect the smoke chemistry and toxicology of cigarettes, compared with older "low-speed-manufacture" adhesives (e.g. starch based).
This study was conducted to determine whether the inclusion of different levels of three adhesives (ethylene vinyl acetate, polyvinyl acetate and starch) in experimental cigarettes results in different smoke chemistry and toxicological responses in in vitro and in vivo assays.
A battery of tests (analytical chemistry, in vitro and in vivo assays) was used to compare the chemistry and toxicology of smoke from experimental cigarettes made with different combinations of the three adhesives. Varying levels of the different side-seam adhesives, as well as the transfer of adhesives from packaging materials, were tested.
There were differences in some mainstream cigarette smoke constituents as a function of the level of adhesive added to experimental cigarettes and between the tested adhesives. None of these differences translated into statistically significant differences in the in vitro or in vivo assays.
The use of newer "high-speed-manufacture" vinyl acetate-based adhesives in cigarettes does not produce toxicological profiles that prevent the adhesives from replacing the older "low-speed-manufacture" adhesives (such as starch).
粘合剂用于香烟生产中的多种不同制造工序。与旧的“低速制造”粘合剂（如淀粉基）相比，新型“高速制造”粘合剂（如醋酸乙烯酯基）的使用可能会影响香烟的烟雾化学和毒理学特性。
本研究旨在确定在实验香烟中加入不同水平的三种粘合剂（乙烯-醋酸乙烯酯、聚醋酸乙烯酯和淀粉）是否会在体外和体内试验中导致不同的烟雾化学和毒理学反应。
使用一系列测试（分析化学、体外和体内试验）来比较由三种粘合剂不同组合制成的实验香烟烟雾的化学和毒理学特性。测试了不同水平的不同侧缝粘合剂以及粘合剂从包装材料的转移情况。
一些主流香烟烟雾成分因添加到实验香烟中的粘合剂水平以及所测试的粘合剂不同而存在差异。但这些差异在体外或体内试验中均未转化为统计学上的显著差异。
在香烟中使用新型“高速制造”醋酸乙烯酯基粘合剂不会产生毒理学特征，从而阻止这些粘合剂替代旧的“低速制造”粘合剂（如淀粉）。
