Coggins Christopher R E, McKinney Willie J, Oldham Michael J
Carson Watts Consulting , King, NC , USA and.
Inhal Toxicol. 2013;25 Suppl 2:69-72. doi: 10.3109/08958378.2013.854436.
Historical work indicates that cigarette circumference may affect the toxicological profile of experimental cigarettes.
Studies were conducted to examine the effect of different cigarette circumferences on (1) selected mainstream smoke constituents including concentrations of tobacco specific nitrosamines (TSNA) in smoke and (2) mutagenicity and cytotoxicity of cigarette smoke condensate.
Analytical chemistry, Salmonella mutagenicity and cytotoxicity assays were used to evaluate the composition and biological activity of mainstream smoke from experimental, non-filtered cigarettes manufactured with four different circumferences (17.0-27.1 mm).
Most smoke constituents, including TSNA, decreased with decreasing cigarette circumference; however, amounts of hydrogen cyanide increased in a non-circumference dependent manner. Mutagenicity and cytotoxicity also decreased slightly with decreasing cigarette circumference.
Cigarette circumference may have a minor role in the toxicological profile of experimental cigarettes, with a so-far-unidentified mechanism.
历史研究表明，卷烟圆周可能会影响实验用卷烟的毒理学特征。
开展研究以考察不同卷烟圆周对以下方面的影响：（1）选定的主流烟气成分，包括烟气中烟草特有亚硝胺（TSNA）的浓度；（2）卷烟烟气冷凝物的致突变性和细胞毒性。
采用分析化学、沙门氏菌致突变性和细胞毒性试验，对用四种不同圆周（17.0 - 27.1毫米）制造的非过滤实验卷烟的主流烟气成分和生物活性进行评估。
包括TSNA在内的大多数烟气成分随卷烟圆周减小而减少；然而，氰化氢的含量以与圆周无关的方式增加。致突变性和细胞毒性也随卷烟圆周减小而略有降低。
卷烟圆周可能在实验用卷烟的毒理学特征方面起较小作用，其机制迄今尚未明确。
