Coggins Christopher R E, Merski Jerome A, Oldham Michael J
Carson Watts Consulting , King, NC , USA and.
Inhal Toxicol. 2013;25 Suppl 2:64-8. doi: 10.3109/08958378.2013.854435.
Manufacture of cigarettes results in tobacco by-products, some of which can be processed and added back to cigarettes. Such additions (known as reconstituted tobacco or reconstituted leaf) have been shown to reduce tar yields. A new process (termed "Deli" cast sheet) is a potential refinement of the reconstitution process.
Compare toxicity of smoke from experimental cigarettes made with reconstituted leaf with that from cigarettes made with Deli cast sheet.
Analytical chemistry, Salmonella mutagenicity and cytotoxicity assays were used to evaluate the composition biological activity of mainstream smoke from experimental cigarettes made with Deli cast sheet or with reconstituted leaf. The effect of different amounts of guar and propylene glycol in Deli cast sheet was also evaluated.
Small increases in the amount of nitrogen oxides were found as a result of inclusion of the Deli cast sheet when compared with reconstituted leaf; no differences in cytotoxicity or mutagenicity were found.
The Deli process neither significantly modified chemical composition of smoke nor affected its biological activity, as measured by the mutagenicity and cytotoxicity assays used here.
香烟制造会产生烟草副产品，其中一些可以经过加工后重新添加到香烟中。这种添加物（称为再造烟草或再造烟叶）已被证明能降低焦油产量。一种新工艺（称为“德利”流延片）是再造工艺的一种潜在改进。
比较用再造烟叶制成的实验香烟烟雾与用德利流延片制成的香烟烟雾的毒性。
采用分析化学、沙门氏菌致突变性和细胞毒性试验，评估用德利流延片或再造烟叶制成的实验香烟主流烟雾的成分生物活性。还评估了德利流延片中不同量的瓜尔胶和丙二醇的影响。
与再造烟叶相比，加入德利流延片后发现氮氧化物含量略有增加；细胞毒性或致突变性未发现差异。
如通过此处使用的致突变性和细胞毒性试验所测定，德利工艺既未显著改变烟雾的化学成分，也未影响其生物活性。
