Coggins Christopher R E, Fisher Michael T, Patskan George J, Oldham Michael J
Carson Watts Consulting , King, NC , USA and.
Inhal Toxicol. 2013;25 Suppl 2:46-58. doi: 10.3109/08958378.2013.854433.
Literature suggests that the width of tobacco strips in cigarettes may affect the smoke chemistry and toxicology of such products.
A comprehensive analysis of smoke from experimental cigarettes can be used to determine whether different cut widths of tobacco result in different toxicological activity.
A battery of tests was used to compare the chemistry and in vitro and in vivo toxicology of smoke from experimental cigarettes made with tobacco cut to different widths.
Different cut widths of tobacco did not elicit consistent and significant differences in cigarette smoke chemistry, responses in in vitro mutagenicity or cytotoxicity assays or most endpoints in 90-d rat inhalation studies. Of note, however, were atypical in-life observations and slightly depressed body weights observed in two rat inhalation studies.
Most of our data indicate that different cut widths of tobacco used in cigarettes are unlikely to change the toxicity of mainstream cigarette smoke; however, without additional investigation, the atypical in-life observations and depression in body weights cast doubt on the toxicological acceptability of cutting the tobacco into wider shreds.
文献表明，香烟中烟丝的宽度可能会影响此类产品的烟雾化学和毒理学。
对实验香烟烟雾进行全面分析，以确定不同切丝宽度的烟草是否会导致不同的毒理学活性。
采用一系列测试来比较由切成不同宽度的烟草制成的实验香烟烟雾的化学性质以及体外和体内毒理学。
不同切丝宽度的烟草在香烟烟雾化学、体外诱变性或细胞毒性试验中的反应或90天大鼠吸入研究的大多数终点方面，并未引发一致且显著的差异。然而，值得注意的是，在两项大鼠吸入研究中观察到了非典型的生命期观察结果以及体重略有下降的情况。
我们的大多数数据表明，香烟中使用的不同切丝宽度的烟草不太可能改变主流香烟烟雾的毒性；然而，在没有进一步调查的情况下，非典型的生命期观察结果和体重下降对将烟草切成更宽碎片的毒理学可接受性提出了质疑。
