巴基斯坦巴哈瓦尔布尔一家三级护理医院 2 型糖尿病视网膜病变的危险因素。
Risk factors of retinopathy in type 2 diabetes mellitus at a tertiary care hospital, Bahawalpur Pakistan.
机构信息
Sadiq Hussain, Department of Pathology, Quaid-e-Azam Medical College (QAMC), Bahawalpur, Pakistan.
Muhammad Rashad Qamar, Department of Ophthalmology, Quaid-e-Azam Medical College (QAMC), Bahawalpur, Pakistan.
出版信息
Pak J Med Sci. 2013 Apr;29(2):536-9. doi: 10.12669/pjms.292.3066.
OBJECTIVES
To find out the risk factors of diabetic retinopathy in type 2 diabetes mellitus.
METHODOLOGY
It was a cross-sectional study involving 300 patients of type 2 diabetes. Clinical history, relevant examination including fundoscopy and lab investigations were done. Data was analysed with SPSS 17.0. T-test and chi square/Fischer exact were applied to determine significance.
RESULTS
Mean age of the patients was 49.04 ± 0.69 years with slight female predominance with male to female ratio of 3:4. Average duration of disease was 7.17 ± 0.38 years. Diabetic retinopathy was diagnosed in (74, 23.9%). Mean HbA1c was 8.15% in patients with retinopathy and 8.884% in those who had no retinopathy (p=0.08). However, duration of DM, age of patients, male gender, high total cholesterol, high LDL and microalbuminuria were significantly associated with the development of retinopathy.
CONCLUSIONS
Diabetic retinopathy was found in 23.9% of type 2 diabetics. It was associated with duration of disease, age at presentation, male gender, high total cholesterol, high LDL and microalbuminuria. A single high level of HbA1c was not associated with retinopathy.
目的
探讨 2 型糖尿病患者糖尿病视网膜病变的危险因素。
方法
这是一项涉及 300 例 2 型糖尿病患者的横断面研究。进行了临床病史、眼底检查和实验室检查等相关检查。使用 SPSS 17.0 进行数据分析。采用 t 检验和卡方/Fischer 精确检验确定显著性。
结果
患者的平均年龄为 49.04±0.69 岁，女性略占优势，男女比例为 3:4。平均病程为 7.17±0.38 年。诊断为糖尿病视网膜病变的患者占 74 例（23.9%）。视网膜病变患者的平均 HbA1c 为 8.15%，无视网膜病变患者的 HbA1c 为 8.884%（p=0.08）。然而，糖尿病的病程、患者的年龄、男性、总胆固醇升高、LDL 升高和微量白蛋白尿与视网膜病变的发生显著相关。
结论
23.9%的 2 型糖尿病患者患有糖尿病视网膜病变。它与疾病的病程、发病时的年龄、男性、总胆固醇升高、LDL 升高和微量白蛋白尿有关。单一高 HbA1c 水平与视网膜病变无关。
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