1Institute of Animal Nutrition, Northeast Agricultural University, Harbin, People's Republic of China.
Reprod Sci. 2014 Jun;21(6):743-53. doi: 10.1177/1933719113512533. Epub 2013 Dec 19.
The objectives of this study were to determine the effects of high-dose and early gestational exposure to zearalenone (ZEN) in female Sprague-Dawley (SD) rats, to correlate the maternal uterus with the fetus, and to explore the development and malformation of fetuses. Pregnant female SD rats were fed diets containing 0.3, 48.5, 97.6, or 146.0 mg/kg ZEN on gestational days (GDs) 0 through 7. All the females survived until GD 20, at which point a cesarean section was performed to harvest the organs, blood, and fetuses. The results indicated that exposure to ZEN during early gestation can impact the maternal reproductive capability. Delayed fetal development was directly linked to maternal toxicity. The toxic effects of ZEN caused early deaths more frequently than late deaths, and the deleterious effects lasted through the end of pregnancy.
本研究旨在确定高剂量和早期妊娠暴露于玉米赤霉烯酮（ZEN）对雌性 Sprague-Dawley（SD）大鼠的影响，将母体子宫与胎儿相关联，并探讨胎儿的发育和畸形。妊娠雌性 SD 大鼠在妊娠第 0 天至第 7 天期间喂食含有 0.3、48.5、97.6 或 146.0mg/kg ZEN 的饮食。所有雌性大鼠存活至妊娠第 20 天，此时进行剖腹产以收获器官、血液和胎儿。结果表明，妊娠早期暴露于 ZEN 会影响母体生殖能力。胎儿发育延迟与母体毒性直接相关。ZEN 的毒性作用导致早期死亡比晚期死亡更频繁，并且有害影响持续到妊娠结束。
