铑（III）催化的酰胺导向吡啶的交叉脱氢杂芳基化反应。

Rh(III)-catalyzed amide-directed cross-dehydrogenative heteroarylation of pyridines.

机构信息

A State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences , Fuzhou, Fujian 350002, China.

出版信息

Org Lett. 2014 Jan 17;16(2):416-9. doi: 10.1021/ol403311b. Epub 2013 Dec 26.

DOI:10.1021/ol403311b

PMID:24369904

Abstract

A new catalytic methodology has been developed for the synthesis of heteroaryled pyridines via a rhodium(III)-catalyzed dehydrogenative cross-coupling reaction. This protocol features a good substrate scope with a broad range of functional group tolerance and high regioselectivity of the pyridyl C-H activation.

摘要

一种新的催化方法已经被开发用于通过铑(III)催化的脱氢交叉偶联反应合成杂芳基吡啶。该方案具有良好的底物范围，对各种官能团具有广泛的耐受性，以及吡啶 C-H 活化的高区域选择性。